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E-mail: biomed@csu.edu.cn
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Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.
| Uniprot primary ID | P08514 |
| PDB ID | 2K9J 1JX5 3ZE0 3ZE1 3ZE2 1KUP 4CAK 2MTP 3NID 3NIF 3NIG 3T3P 3T3M 3ZDZ 3ZDY 3ZDX 2VDK 2VDL 2VDM 2VDN 2VDO 1KUZ 3FCU 2KNC 3FCS 1S4W 1RN0 2VDP 2VDQ 2VDR 1TYE 1DPQ 1M8O 1DPK 1UV9 2K1A 2VC2 |
| DrugBank ID | DB00054 DB00775 |
| BioGrid ID | 109881 |
| GuidetoPHARMACOLOGY ID | |
| PharmGKB ID | PA29938 |
| KEGG ID | hsa:3674 |
| DIP ID | DIP-68N |
| STRING ID | 9606.ENSP00000262407 |
| IntAct ID | P08514 |
| DMDM | 226694183 |
| BRENDA | |
| Reactome | R-HSA-216083 R-HSA-445144 R-HSA-114608 R-HSA-354194 R-HSA-354192 R-HSA-3000178 R-HSA-372708 R-HSA-5674135 |
| SignaLink | P08514 |
| BioCyc | |
| Entrez Gene (Gene ID) | 3674 |
| BindingDB | P08514 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.849 | 0.003 | 0.889 | 0.000 | 0.869 | 0.003 | 0.863 | 0.005 | 0.950 | 0.000 | 0.735 | 0.005 | Download |
| Estate fingerprints | 0.930 | 0.000 | 0.850 | 0.005 | 0.890 | 0.000 | 0.893 | 0.005 | 0.950 | 0.000 | 0.780 | 0.000 | Download |
| MACCS fingerprints | 0.940 | 0.000 | 0.888 | 0.000 | 0.914 | 0.005 | 0.920 | 0.000 | 0.970 | 0.000 | 0.830 | 0.000 | Download |
| Daylight fingerprints | 0.830 | 0.000 | 0.752 | 0.000 | 0.791 | 0.003 | 0.800 | 0.000 | 0.850 | 0.000 | 0.589 | 0.003 | Download |
| ECFP2 fingerprints | 0.990 | 0.000 | 0.940 | 0.005 | 0.965 | 0.005 | 0.969 | 0.003 | 0.990 | 0.000 | 0.930 | 0.000 | Download |
| ECFP4 fingerprints | 0.990 | 0.000 | 0.970 | 0.005 | 0.980 | 0.000 | 0.980 | 0.000 | 1.000 | 0.000 | 0.958 | 0.004 | Download |
| ECFP6 fingerprints | 0.980 | 0.000 | 0.980 | 0.000 | 0.980 | 0.000 | 0.980 | 0.000 | 1.000 | 0.000 | 0.962 | 0.004 | Download |
| Positive dataset | Negative dataset |
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E-mail: biomed@csu.edu.cn
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