Details-Calcnet-TargetNet

Target name

P08575: Receptor-type tyrosine-protein phosphatase C

Protein function

Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity).

Database links

Uniprot primary ID	P08575
PDB ID	1YGU 1YGR
DrugBank ID
BioGrid ID	111752
GuidetoPHARMACOLOGY ID	1852
PharmGKB ID	PA34011
KEGG ID
DIP ID	DIP-224N
STRING ID	9606.ENSP00000356346
IntAct ID	P08575
DMDM	33112650
BRENDA
Reactome	R-HSA-416700 R-HSA-202427
SignaLink	P08575
BioCyc
Entrez Gene (Gene ID)	5788
BindingDB	P08575

Model Performance Metrics

Fingerprint type	Sensitivity	SEN_std	Specificity	SPE_std	Accuracy	ACC_std	F1-score	F1-score_std	AUC	AUC_std	MCC	MCC_std	Download model
FP2 fingerprints	0.853	0.008	0.953	0.006	0.903	0.005	0.900	0.007	0.969	0.003	0.810	0.012	Download
Estate fingerprints	0.856	0.007	0.834	0.009	0.845	0.005	0.845	0.005	0.909	0.003	0.686	0.012	Download
MACCS fingerprints	0.862	0.010	0.890	0.012	0.876	0.010	0.875	0.008	0.921	0.003	0.748	0.015	Download
Daylight fingerprints	0.687	0.013	0.985	0.004	0.836	0.007	0.806	0.007	0.948	0.009	0.704	0.010	Download
ECFP2 fingerprints	0.965	0.010	0.909	0.007	0.937	0.007	0.937	0.007	0.979	0.003	0.876	0.012	Download
ECFP4 fingerprints	0.947	0.005	0.913	0.011	0.930	0.007	0.930	0.007	0.975	0.005	0.859	0.007	Download
ECFP6 fingerprints	0.928	0.006	0.964	0.007	0.946	0.005	0.942	0.004	0.976	0.005	0.887	0.009	Download

Download datasets

Positive dataset

Negative dataset