Target name

P08575: Receptor-type tyrosine-protein phosphatase C


  Protein function

Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity).

  Database links

Uniprot primary ID P08575
PDB ID 1YGU 1YGR
DrugBank ID
BioGrid ID 111752
GuidetoPHARMACOLOGY ID 1852
PharmGKB ID PA34011
KEGG ID
DIP ID DIP-224N
STRING ID 9606.ENSP00000356346
IntAct ID P08575
DMDM 33112650
BRENDA
Reactome R-HSA-416700 R-HSA-202427
SignaLink P08575
BioCyc
Entrez Gene (Gene ID) 5788
BindingDB P08575

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.853 0.008 0.953 0.006 0.903 0.005 0.900 0.007 0.969 0.003 0.810 0.012 Download
Estate fingerprints 0.856 0.007 0.834 0.009 0.845 0.005 0.845 0.005 0.909 0.003 0.686 0.012 Download
MACCS fingerprints 0.862 0.010 0.890 0.012 0.876 0.010 0.875 0.008 0.921 0.003 0.748 0.015 Download
Daylight fingerprints 0.687 0.013 0.985 0.004 0.836 0.007 0.806 0.007 0.948 0.009 0.704 0.010 Download
ECFP2 fingerprints 0.965 0.010 0.909 0.007 0.937 0.007 0.937 0.007 0.979 0.003 0.876 0.012 Download
ECFP4 fingerprints 0.947 0.005 0.913 0.011 0.930 0.007 0.930 0.007 0.975 0.005 0.859 0.007 Download
ECFP6 fingerprints 0.928 0.006 0.964 0.007 0.946 0.005 0.942 0.004 0.976 0.005 0.887 0.009 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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