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E-mail: biomed@csu.edu.cn
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Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling.
| Uniprot primary ID | P08588 |
| PDB ID | 2LSQ |
| DrugBank ID | DB01288 DB01064 DB00598 DB08808 DB00221 DB01102 DB08807 |
| BioGrid ID | 106662 |
| GuidetoPHARMACOLOGY ID | 28 |
| PharmGKB ID | PA38 |
| KEGG ID | hsa:153 |
| DIP ID | DIP-36294N |
| STRING ID | 9606.ENSP00000358301 |
| IntAct ID | P08588 |
| DMDM | 48429211 |
| BRENDA | |
| Reactome | R-HSA-418555 R-HSA-390696 |
| SignaLink | P08588 |
| BioCyc | |
| Entrez Gene (Gene ID) | 153 |
| BindingDB | P08588 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.900 | 0.000 | 0.960 | 0.005 | 0.930 | 0.000 | 0.925 | 0.005 | 0.957 | 0.005 | 0.855 | 0.005 | Download |
| Estate fingerprints | 0.890 | 0.000 | 0.876 | 0.005 | 0.883 | 0.005 | 0.884 | 0.005 | 0.940 | 0.000 | 0.770 | 0.000 | Download |
| MACCS fingerprints | 0.900 | 0.000 | 0.900 | 0.004 | 0.900 | 0.000 | 0.900 | 0.000 | 0.950 | 0.000 | 0.797 | 0.005 | Download |
| Daylight fingerprints | 0.830 | 0.000 | 0.816 | 0.000 | 0.823 | 0.005 | 0.827 | 0.005 | 0.867 | 0.005 | 0.650 | 0.000 | Download |
| ECFP2 fingerprints | 0.920 | 0.000 | 0.980 | 0.000 | 0.950 | 0.000 | 0.950 | 0.000 | 0.970 | 0.000 | 0.900 | 0.000 | Download |
| ECFP4 fingerprints | 0.920 | 0.000 | 1.000 | 0.000 | 0.960 | 0.000 | 0.960 | 0.000 | 0.970 | 0.000 | 0.920 | 0.000 | Download |
| ECFP6 fingerprints | 0.900 | 0.000 | 1.000 | 0.000 | 0.950 | 0.000 | 0.950 | 0.000 | 0.970 | 0.000 | 0.900 | 0.000 | Download |
| Positive dataset | Negative dataset |
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E-mail: biomed@csu.edu.cn
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