Target name

P08588: Beta-1 adrenergic receptor


  Protein function

Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling.

  Database links

Uniprot primary ID P08588
PDB ID 2LSQ
DrugBank ID DB01288 DB01064 DB00598 DB08808 DB00221 DB01102 DB08807
BioGrid ID 106662
GuidetoPHARMACOLOGY ID 28
PharmGKB ID PA38
KEGG ID hsa:153
DIP ID DIP-36294N
STRING ID 9606.ENSP00000358301
IntAct ID P08588
DMDM 48429211
BRENDA
Reactome R-HSA-418555 R-HSA-390696
SignaLink P08588
BioCyc
Entrez Gene (Gene ID) 153
BindingDB P08588

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.900 0.000 0.960 0.005 0.930 0.000 0.925 0.005 0.957 0.005 0.855 0.005 Download
Estate fingerprints 0.890 0.000 0.876 0.005 0.883 0.005 0.884 0.005 0.940 0.000 0.770 0.000 Download
MACCS fingerprints 0.900 0.000 0.900 0.004 0.900 0.000 0.900 0.000 0.950 0.000 0.797 0.005 Download
Daylight fingerprints 0.830 0.000 0.816 0.000 0.823 0.005 0.827 0.005 0.867 0.005 0.650 0.000 Download
ECFP2 fingerprints 0.920 0.000 0.980 0.000 0.950 0.000 0.950 0.000 0.970 0.000 0.900 0.000 Download
ECFP4 fingerprints 0.920 0.000 1.000 0.000 0.960 0.000 0.960 0.000 0.970 0.000 0.920 0.000 Download
ECFP6 fingerprints 0.900 0.000 1.000 0.000 0.950 0.000 0.950 0.000 0.970 0.000 0.900 0.000 Download

  Download datasets

Positive dataset Negative dataset


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 E-mail: biomed@csu.edu.cn