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E-mail: biomed@csu.edu.cn
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G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli.
| Uniprot primary ID | P08908 |
| PDB ID | |
| DrugBank ID | DB00952 DB06148 DB01142 DB01049 DB08807 DB01622 DB00246 |
| BioGrid ID | 109582 |
| GuidetoPHARMACOLOGY ID | 1 |
| PharmGKB ID | PA192 |
| KEGG ID | hsa:3350 |
| DIP ID | |
| STRING ID | 9606.ENSP00000316244 |
| IntAct ID | P08908 |
| DMDM | 231454 |
| BRENDA | |
| Reactome | R-HSA-418594 R-HSA-390666 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 3350 |
| BindingDB | P08908 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.850 | 0.000 | 0.790 | 0.003 | 0.820 | 0.000 | 0.827 | 0.005 | 0.900 | 0.000 | 0.642 | 0.004 | Download |
| Estate fingerprints | 0.830 | 0.000 | 0.730 | 0.004 | 0.780 | 0.000 | 0.790 | 0.000 | 0.840 | 0.000 | 0.560 | 0.000 | Download |
| MACCS fingerprints | 0.830 | 0.000 | 0.710 | 0.000 | 0.770 | 0.000 | 0.783 | 0.005 | 0.860 | 0.000 | 0.550 | 0.000 | Download |
| Daylight fingerprints | 0.740 | 0.000 | 0.740 | 0.005 | 0.740 | 0.000 | 0.740 | 0.000 | 0.790 | 0.000 | 0.487 | 0.005 | Download |
| ECFP2 fingerprints | 0.920 | 0.000 | 0.860 | 0.000 | 0.890 | 0.000 | 0.890 | 0.000 | 0.950 | 0.000 | 0.775 | 0.005 | Download |
| ECFP4 fingerprints | 0.900 | 0.000 | 0.916 | 0.004 | 0.908 | 0.004 | 0.906 | 0.005 | 0.960 | 0.000 | 0.810 | 0.000 | Download |
| ECFP6 fingerprints | 0.851 | 0.003 | 0.947 | 0.000 | 0.899 | 0.003 | 0.890 | 0.000 | 0.960 | 0.000 | 0.795 | 0.005 | Download |
| Positive dataset | Negative dataset |
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E-mail: biomed@csu.edu.cn
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