Target name

P08908: 5-hydroxytryptamine receptor 1A


  Protein function

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli.

  Database links

Uniprot primary ID P08908
PDB ID
DrugBank ID DB00952 DB06148 DB01142 DB01049 DB08807 DB01622 DB00246
BioGrid ID 109582
GuidetoPHARMACOLOGY ID 1
PharmGKB ID PA192
KEGG ID hsa:3350
DIP ID
STRING ID 9606.ENSP00000316244
IntAct ID P08908
DMDM 231454
BRENDA
Reactome R-HSA-418594 R-HSA-390666
SignaLink
BioCyc
Entrez Gene (Gene ID) 3350
BindingDB P08908

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.850 0.000 0.790 0.003 0.820 0.000 0.827 0.005 0.900 0.000 0.642 0.004 Download
Estate fingerprints 0.830 0.000 0.730 0.004 0.780 0.000 0.790 0.000 0.840 0.000 0.560 0.000 Download
MACCS fingerprints 0.830 0.000 0.710 0.000 0.770 0.000 0.783 0.005 0.860 0.000 0.550 0.000 Download
Daylight fingerprints 0.740 0.000 0.740 0.005 0.740 0.000 0.740 0.000 0.790 0.000 0.487 0.005 Download
ECFP2 fingerprints 0.920 0.000 0.860 0.000 0.890 0.000 0.890 0.000 0.950 0.000 0.775 0.005 Download
ECFP4 fingerprints 0.900 0.000 0.916 0.004 0.908 0.004 0.906 0.005 0.960 0.000 0.810 0.000 Download
ECFP6 fingerprints 0.851 0.003 0.947 0.000 0.899 0.003 0.890 0.000 0.960 0.000 0.795 0.005 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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