Target name

P11362: Fibroblast growth factor receptor 1


  Protein function

Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation.

  Database links

Uniprot primary ID P11362
PDB ID 4WUN 4ZSA 3GQI 5A4C 1XR0 3WJ6 3KXX 4F64 4F65 4F63 4NKS 4UWB 4UWC 2FGI 3GQL 3C4F 2CR3 4NKA 5AM7 1FQ9 4RWK 4RWJ 4RWI 3KY2 3OJV 4RWL 1AGW 3JS2 4NK9 5AM6 4UWY 3DPK 1CVS 3KRJ 3KRL 1FGI 1FGK 3RHX 1EVT 3TT0 5A46 4V04 4V05 4V01
DrugBank ID DB09079 DB09078 DB08896 DB08901 DB00398 DB00039
BioGrid ID 108551
GuidetoPHARMACOLOGY ID 1808
PharmGKB ID PA28127
KEGG ID hsa:2260
DIP ID DIP-4019N
STRING ID 9606.ENSP00000393312
IntAct ID P11362
DMDM 120046
BRENDA 2.7.10.1
Reactome R-HSA-445144 R-HSA-190374 R-HSA-190373 R-HSA-190370 R-HSA-5654219 R-HSA-5654689 R-HSA-5654688 R-HSA-2219530 R-HSA-5654726 R-HSA-5655302 R-HSA-375165 R-HSA-5654693 R-HSA-1257604 R-HSA-1839120 R-HSA-109704 R-HSA-1839122 R-HSA-5673001
SignaLink P11362
BioCyc
Entrez Gene (Gene ID) 2260
BindingDB P11362

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.895 0.005 0.905 0.004 0.900 0.000 0.900 0.000 0.949 0.003 0.800 0.005 Download
Estate fingerprints 0.818 0.004 0.766 0.003 0.792 0.004 0.800 0.000 0.874 0.005 0.586 0.005 Download
MACCS fingerprints 0.840 0.000 0.760 0.004 0.800 0.000 0.809 0.003 0.882 0.004 0.603 0.005 Download
Daylight fingerprints 0.830 0.007 0.886 0.005 0.858 0.004 0.853 0.005 0.920 0.000 0.717 0.005 Download
ECFP2 fingerprints 0.947 0.005 0.889 0.004 0.918 0.004 0.920 0.000 0.980 0.000 0.835 0.005 Download
ECFP4 fingerprints 0.894 0.005 0.974 0.003 0.934 0.005 0.930 0.000 0.980 0.000 0.869 0.003 Download
ECFP6 fingerprints 0.877 0.005 0.987 0.000 0.932 0.004 0.930 0.000 0.970 0.000 0.872 0.004 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

The recommended browsers: Safari, Firefox, Chrome, IE(Ver.>8).
 E-mail: biomed@csu.edu.cn