Target name

P11511: Aromatase


  Protein function

Catalyzes the formation of aromatic C18 estrogens from C19 androgens.

  Database links

Uniprot primary ID P11511
PDB ID 4KQ8 4GL7 3EQM 3S79 4GL5 1TQA 3S7S
DrugBank ID DB01065 DB00974 DB00675 DB04839 DB01026 DB06147 DB00389
BioGrid ID 107960
GuidetoPHARMACOLOGY ID 1362
PharmGKB ID PA27091
KEGG ID hsa:1588
DIP ID
STRING ID 9606.ENSP00000260433
IntAct ID P11511
DMDM 117293
BRENDA 1.14.14.14
Reactome R-HSA-5579030 R-HSA-193144 R-HSA-211976
SignaLink
BioCyc MetaCyc:HS06413-MONOMER
Entrez Gene (Gene ID) 1588
BindingDB P11511

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.866 0.005 0.854 0.005 0.860 0.000 0.860 0.000 0.940 0.000 0.721 0.003 Download
Estate fingerprints 0.833 0.005 0.827 0.000 0.830 0.000 0.830 0.000 0.910 0.000 0.655 0.005 Download
MACCS fingerprints 0.875 0.005 0.845 0.000 0.860 0.000 0.860 0.000 0.930 0.000 0.716 0.005 Download
Daylight fingerprints 0.707 0.005 0.829 0.005 0.768 0.004 0.751 0.003 0.850 0.000 0.538 0.004 Download
ECFP2 fingerprints 0.960 0.000 0.920 0.000 0.940 0.000 0.940 0.000 0.990 0.000 0.884 0.005 Download
ECFP4 fingerprints 0.964 0.005 0.956 0.000 0.960 0.000 0.960 0.000 0.990 0.000 0.917 0.005 Download
ECFP6 fingerprints 0.960 0.000 0.960 0.004 0.960 0.000 0.960 0.000 0.990 0.000 0.915 0.005 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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