Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.
| Uniprot primary ID | P12268 |
| PDB ID | 1NF7 1B3O 1NFB |
| DrugBank ID | DB01033 DB00688 DB01024 |
| BioGrid ID | 109828 |
| GuidetoPHARMACOLOGY ID | 2625 |
| PharmGKB ID | PA29863 |
| KEGG ID | hsa:3615 |
| DIP ID | |
| STRING ID | 9606.ENSP00000321584 |
| IntAct ID | P12268 |
| DMDM | 124419 |
| BRENDA | 1.1.1.205 |
| Reactome | R-HSA-73817 |
| SignaLink | |
| BioCyc | MetaCyc:HS11242-MONOMER |
| Entrez Gene (Gene ID) | 3615 |
| BindingDB | P12268 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.805 | 0.005 | 0.971 | 0.000 | 0.888 | 0.004 | 0.877 | 0.005 | 0.979 | 0.003 | 0.786 | 0.005 | Download |
| Estate fingerprints | 0.847 | 0.005 | 0.835 | 0.005 | 0.841 | 0.003 | 0.841 | 0.003 | 0.922 | 0.004 | 0.681 | 0.007 | Download |
| MACCS fingerprints | 0.841 | 0.003 | 0.819 | 0.005 | 0.830 | 0.000 | 0.830 | 0.000 | 0.901 | 0.003 | 0.659 | 0.006 | Download |
| Daylight fingerprints | 0.708 | 0.004 | 0.990 | 0.004 | 0.849 | 0.003 | 0.822 | 0.006 | 0.931 | 0.003 | 0.724 | 0.007 | Download |
| ECFP2 fingerprints | 0.941 | 0.003 | 0.949 | 0.003 | 0.945 | 0.005 | 0.945 | 0.005 | 0.990 | 0.000 | 0.891 | 0.006 | Download |
| ECFP4 fingerprints | 0.970 | 0.000 | 0.990 | 0.000 | 0.980 | 0.000 | 0.980 | 0.000 | 1.000 | 0.000 | 0.960 | 0.000 | Download |
| ECFP6 fingerprints | 0.957 | 0.005 | 0.997 | 0.005 | 0.977 | 0.005 | 0.977 | 0.005 | 1.000 | 0.000 | 0.957 | 0.005 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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