Target name

P12268: Inosine-5'-monophosphate dehydrogenase 2


  Protein function

Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.

  Database links

Uniprot primary ID P12268
PDB ID 1NF7 1B3O 1NFB
DrugBank ID DB01033 DB00688 DB01024
BioGrid ID 109828
GuidetoPHARMACOLOGY ID 2625
PharmGKB ID PA29863
KEGG ID hsa:3615
DIP ID
STRING ID 9606.ENSP00000321584
IntAct ID P12268
DMDM 124419
BRENDA 1.1.1.205
Reactome R-HSA-73817
SignaLink
BioCyc MetaCyc:HS11242-MONOMER
Entrez Gene (Gene ID) 3615
BindingDB P12268

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.805 0.005 0.971 0.000 0.888 0.004 0.877 0.005 0.979 0.003 0.786 0.005 Download
Estate fingerprints 0.847 0.005 0.835 0.005 0.841 0.003 0.841 0.003 0.922 0.004 0.681 0.007 Download
MACCS fingerprints 0.841 0.003 0.819 0.005 0.830 0.000 0.830 0.000 0.901 0.003 0.659 0.006 Download
Daylight fingerprints 0.708 0.004 0.990 0.004 0.849 0.003 0.822 0.006 0.931 0.003 0.724 0.007 Download
ECFP2 fingerprints 0.941 0.003 0.949 0.003 0.945 0.005 0.945 0.005 0.990 0.000 0.891 0.006 Download
ECFP4 fingerprints 0.970 0.000 0.990 0.000 0.980 0.000 0.980 0.000 1.000 0.000 0.960 0.000 Download
ECFP6 fingerprints 0.957 0.005 0.997 0.005 0.977 0.005 0.977 0.005 1.000 0.000 0.957 0.005 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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