Target name

P13497: Bone morphogenetic protein 1


  Protein function

Cleaves the C-terminal propeptides of procollagen I, II and III. Induces cartilage and bone formation. May participate in dorsoventral patterning during early development by cleaving chordin (CHRD). Responsible for the proteolytic activation of lysyl oxidase LOX.

  Database links

Uniprot primary ID P13497
PDB ID 3EDG 3EDH
DrugBank ID
BioGrid ID 107117
GuidetoPHARMACOLOGY ID 2333
PharmGKB ID PA25377
KEGG ID hsa:649
DIP ID DIP-33403N
STRING ID 9606.ENSP00000305714
IntAct ID P13497
DMDM 13124688
BRENDA 3.4.24.19
Reactome R-HSA-1650814 R-HSA-2214320 R-HSA-2243919 R-HSA-194223 R-HSA-1474228
SignaLink
BioCyc
Entrez Gene (Gene ID) 649
BindingDB P13497

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.951 0.006 0.975 0.005 0.963 0.005 0.961 0.003 0.990 0.000 0.928 0.006 Download
Estate fingerprints 0.980 0.000 0.920 0.004 0.950 0.000 0.950 0.000 0.990 0.000 0.901 0.003 Download
MACCS fingerprints 1.000 0.000 0.940 0.005 0.970 0.000 0.970 0.000 0.990 0.000 0.939 0.003 Download
Daylight fingerprints 0.830 0.009 0.994 0.000 0.912 0.006 0.904 0.007 0.990 0.000 0.836 0.007 Download
ECFP2 fingerprints 1.000 0.000 0.980 0.003 0.990 0.000 0.990 0.000 1.000 0.000 0.971 0.003 Download
ECFP4 fingerprints 1.000 0.000 1.000 0.005 1.000 0.000 1.000 0.000 1.000 0.000 0.995 0.005 Download
ECFP6 fingerprints 1.000 0.000 1.000 0.000 1.000 0.000 1.000 0.000 1.000 0.000 0.990 0.000 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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