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E-mail: biomed@csu.edu.cn
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Cleaves the C-terminal propeptides of procollagen I, II and III. Induces cartilage and bone formation. May participate in dorsoventral patterning during early development by cleaving chordin (CHRD). Responsible for the proteolytic activation of lysyl oxidase LOX.
| Uniprot primary ID | P13497 |
| PDB ID | 3EDG 3EDH |
| DrugBank ID | |
| BioGrid ID | 107117 |
| GuidetoPHARMACOLOGY ID | 2333 |
| PharmGKB ID | PA25377 |
| KEGG ID | hsa:649 |
| DIP ID | DIP-33403N |
| STRING ID | 9606.ENSP00000305714 |
| IntAct ID | P13497 |
| DMDM | 13124688 |
| BRENDA | 3.4.24.19 |
| Reactome | R-HSA-1650814 R-HSA-2214320 R-HSA-2243919 R-HSA-194223 R-HSA-1474228 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 649 |
| BindingDB | P13497 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.951 | 0.006 | 0.975 | 0.005 | 0.963 | 0.005 | 0.961 | 0.003 | 0.990 | 0.000 | 0.928 | 0.006 | Download |
| Estate fingerprints | 0.980 | 0.000 | 0.920 | 0.004 | 0.950 | 0.000 | 0.950 | 0.000 | 0.990 | 0.000 | 0.901 | 0.003 | Download |
| MACCS fingerprints | 1.000 | 0.000 | 0.940 | 0.005 | 0.970 | 0.000 | 0.970 | 0.000 | 0.990 | 0.000 | 0.939 | 0.003 | Download |
| Daylight fingerprints | 0.830 | 0.009 | 0.994 | 0.000 | 0.912 | 0.006 | 0.904 | 0.007 | 0.990 | 0.000 | 0.836 | 0.007 | Download |
| ECFP2 fingerprints | 1.000 | 0.000 | 0.980 | 0.003 | 0.990 | 0.000 | 0.990 | 0.000 | 1.000 | 0.000 | 0.971 | 0.003 | Download |
| ECFP4 fingerprints | 1.000 | 0.000 | 1.000 | 0.005 | 1.000 | 0.000 | 1.000 | 0.000 | 1.000 | 0.000 | 0.995 | 0.005 | Download |
| ECFP6 fingerprints | 1.000 | 0.000 | 1.000 | 0.000 | 1.000 | 0.000 | 1.000 | 0.000 | 1.000 | 0.000 | 0.990 | 0.000 | Download |
| Positive dataset | Negative dataset |
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E-mail: biomed@csu.edu.cn
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