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Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (PubMed:11500518, PubMed:11533264, PubMed:16275639, PubMed:16443825, PubMed:26098370). Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids (PubMed:11500518, PubMed:11533264, PubMed:16443825, PubMed:26098370). Plays an important role in lipid biosynthesis (PubMed:17127673, PubMed:10899171, PubMed:11500518, PubMed:11441127, PubMed:11533264, PubMed:12177411, PubMed:26098370). Plays an important role in regulating the expression of genes that are involved in lipogenesis and in regulating mitochondrial fatty acid oxidation (PubMed:12177411, PubMed:17127673, PubMed:24356954, PubMed:24295027). Plays an important role in body energy homeostasis (PubMed:17127673, PubMed:15210843, PubMed:24295027, PubMed:24356954). Contributes to the biosynthesis of membrane phospholipids, cholesterol esters and triglycerides (PubMed:10899171, PubMed:11500518, PubMed:11441127, PubMed:11533264, PubMed:12177411, PubMed:15210843, PubMed:26098370). Required for normal development of sebaceous glands (PubMed:17738154, PubMed:11533264). Required for the biosynthesis of normal levels of delta-9 unsaturated fatty acids and 1-alkyl-2,3-diacylglycerol in the Harderian gland (PubMed:11500518). Required for normal production of meibum, an oily material that prevents drying of the cornea (PubMed:11533264).
| Uniprot primary ID | P13516 |
| PDB ID | 4YMK |
| DrugBank ID | |
| BioGrid ID | |
| GuidetoPHARMACOLOGY ID | |
| PharmGKB ID | |
| KEGG ID | mmu:20249 |
| DIP ID | |
| STRING ID | 10090.ENSMUSP00000036936 |
| IntAct ID | |
| DMDM | |
| BRENDA | 1.14.19.1 |
| Reactome | |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 20249 |
| BindingDB | P13516 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.913 | 0.005 | 1.000 | 0.000 | 0.959 | 0.003 | 0.953 | 0.005 | 1.000 | 0.000 | 0.921 | 0.006 | Download |
| Estate fingerprints | 0.935 | 0.011 | 0.891 | 0.006 | 0.913 | 0.005 | 0.915 | 0.007 | 0.970 | 0.000 | 0.823 | 0.014 | Download |
| MACCS fingerprints | 0.940 | 0.000 | 0.922 | 0.003 | 0.931 | 0.003 | 0.931 | 0.003 | 0.971 | 0.003 | 0.867 | 0.005 | Download |
| Daylight fingerprints | 0.915 | 0.008 | 0.999 | 0.000 | 0.957 | 0.005 | 0.957 | 0.005 | 0.990 | 0.000 | 0.918 | 0.006 | Download |
| ECFP2 fingerprints | 1.000 | 0.000 | 0.980 | 0.003 | 0.990 | 0.000 | 0.990 | 0.000 | 1.000 | 0.000 | 0.986 | 0.005 | Download |
| ECFP4 fingerprints | 0.997 | 0.005 | 1.000 | 0.000 | 1.000 | 0.000 | 1.000 | 0.000 | 1.000 | 0.000 | 0.997 | 0.005 | Download |
| ECFP6 fingerprints | 0.987 | 0.005 | 0.993 | 0.000 | 0.990 | 0.000 | 0.990 | 0.000 | 1.000 | 0.000 | 0.987 | 0.005 | Download |
| Positive dataset | Negative dataset |
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E-mail: biomed@csu.edu.cn
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