TargetNet
  Target name

P13945: Beta-3 adrenergic receptor

  Protein function

Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis.

  Database links
Uniprot primary ID P13945
PDB ID 2CDW
DrugBank ID DB01363 DB01288 DB08808 DB01365 DB01102 DB00334 DB08893
BioGrid ID 106664
GuidetoPHARMACOLOGY ID 30
PharmGKB ID PA24598
KEGG ID hsa:155
DIP ID DIP-61451N
STRING ID 9606.ENSP00000343782
IntAct ID P13945
DMDM 461604
BRENDA
Reactome R-HSA-418555 R-HSA-390696
SignaLink
BioCyc
Entrez Gene (Gene ID) 155
BindingDB P13945
  Model Performance Metrics
Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.967 0.005 0.973 0.000 0.970 0.000 0.970 0.000 0.990 0.000 0.940 0.000 Download
Estate fingerprints 0.920 0.000 0.880 0.005 0.900 0.000 0.901 0.003 0.970 0.000 0.806 0.005 Download
MACCS fingerprints 0.888 0.004 0.932 0.000 0.910 0.000 0.908 0.004 0.970 0.000 0.817 0.005 Download
Daylight fingerprints 0.867 0.005 0.841 0.005 0.854 0.005 0.859 0.003 0.901 0.003 0.709 0.003 Download
ECFP2 fingerprints 0.961 0.003 0.997 0.000 0.979 0.003 0.979 0.003 1.000 0.000 0.951 0.003 Download
ECFP4 fingerprints 0.969 0.003 0.991 0.000 0.980 0.000 0.980 0.000 1.000 0.000 0.960 0.000 Download
ECFP6 fingerprints 0.950 0.000 0.992 0.005 0.971 0.003 0.970 0.000 1.000 0.000 0.950 0.000 Download
  Download datasets
Positive dataset Negative dataset

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 E-mail: biomed@csu.edu.cn