Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis.
| Uniprot primary ID | P13945 |
| PDB ID | 2CDW |
| DrugBank ID | DB01363 DB01288 DB08808 DB01365 DB01102 DB00334 DB08893 |
| BioGrid ID | 106664 |
| GuidetoPHARMACOLOGY ID | 30 |
| PharmGKB ID | PA24598 |
| KEGG ID | hsa:155 |
| DIP ID | DIP-61451N |
| STRING ID | 9606.ENSP00000343782 |
| IntAct ID | P13945 |
| DMDM | 461604 |
| BRENDA | |
| Reactome | R-HSA-418555 R-HSA-390696 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 155 |
| BindingDB | P13945 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.967 | 0.005 | 0.973 | 0.000 | 0.970 | 0.000 | 0.970 | 0.000 | 0.990 | 0.000 | 0.940 | 0.000 | Download |
| Estate fingerprints | 0.920 | 0.000 | 0.880 | 0.005 | 0.900 | 0.000 | 0.901 | 0.003 | 0.970 | 0.000 | 0.806 | 0.005 | Download |
| MACCS fingerprints | 0.888 | 0.004 | 0.932 | 0.000 | 0.910 | 0.000 | 0.908 | 0.004 | 0.970 | 0.000 | 0.817 | 0.005 | Download |
| Daylight fingerprints | 0.867 | 0.005 | 0.841 | 0.005 | 0.854 | 0.005 | 0.859 | 0.003 | 0.901 | 0.003 | 0.709 | 0.003 | Download |
| ECFP2 fingerprints | 0.961 | 0.003 | 0.997 | 0.000 | 0.979 | 0.003 | 0.979 | 0.003 | 1.000 | 0.000 | 0.951 | 0.003 | Download |
| ECFP4 fingerprints | 0.969 | 0.003 | 0.991 | 0.000 | 0.980 | 0.000 | 0.980 | 0.000 | 1.000 | 0.000 | 0.960 | 0.000 | Download |
| ECFP6 fingerprints | 0.950 | 0.000 | 0.992 | 0.005 | 0.971 | 0.003 | 0.970 | 0.000 | 1.000 | 0.000 | 0.950 | 0.000 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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