Target name

P14416: D(2) dopamine receptor


  Protein function

Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase.

  Database links

Uniprot primary ID P14416
PDB ID 5AER 1I15
DrugBank ID DB00777 DB06148 DB01100 DB01142 DB01063 DB01624 DB01221
BioGrid ID 108147
GuidetoPHARMACOLOGY ID 215
PharmGKB ID PA27478
KEGG ID hsa:1813
DIP ID DIP-5977N
STRING ID 9606.ENSP00000354859
IntAct ID P14416
DMDM 118206
BRENDA
Reactome R-HSA-418594 R-HSA-390651
SignaLink P14416
BioCyc
Entrez Gene (Gene ID) 1813
BindingDB P14416

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.830 0.000 0.770 0.000 0.800 0.000 0.810 0.000 0.890 0.000 0.600 0.000 Download
Estate fingerprints 0.850 0.000 0.730 0.000 0.790 0.000 0.800 0.000 0.860 0.000 0.580 0.000 Download
MACCS fingerprints 0.860 0.000 0.724 0.000 0.792 0.004 0.810 0.000 0.880 0.000 0.592 0.004 Download
Daylight fingerprints 0.690 0.000 0.730 0.000 0.710 0.000 0.700 0.000 0.760 0.000 0.410 0.000 Download
ECFP2 fingerprints 0.920 0.000 0.860 0.000 0.890 0.000 0.890 0.000 0.959 0.003 0.780 0.000 Download
ECFP4 fingerprints 0.910 0.000 0.910 0.000 0.910 0.000 0.910 0.000 0.960 0.000 0.817 0.005 Download
ECFP6 fingerprints 0.870 0.000 0.930 0.000 0.900 0.000 0.890 0.000 0.960 0.000 0.791 0.003 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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