G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca(2+) ions from intracellular stores. Affects neural activity, perception, cognition and mood. Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction.
| Uniprot primary ID | P14842 |
| PDB ID | 4OAJ |
| DrugBank ID | |
| BioGrid ID | 248227 |
| GuidetoPHARMACOLOGY ID | 6 |
| PharmGKB ID | |
| KEGG ID | rno:29595 |
| DIP ID | DIP-57661N |
| STRING ID | 10116.ENSRNOP00000013408 |
| IntAct ID | P14842 |
| DMDM | |
| BRENDA | |
| Reactome | R-RNO-390666 R-RNO-416476 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 29595 |
| BindingDB | P14842 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.880 | 0.000 | 0.760 | 0.004 | 0.820 | 0.000 | 0.830 | 0.000 | 0.900 | 0.000 | 0.647 | 0.005 | Download |
| Estate fingerprints | 0.821 | 0.006 | 0.745 | 0.003 | 0.783 | 0.005 | 0.790 | 0.000 | 0.860 | 0.000 | 0.568 | 0.004 | Download |
| MACCS fingerprints | 0.842 | 0.004 | 0.738 | 0.000 | 0.790 | 0.000 | 0.800 | 0.000 | 0.860 | 0.000 | 0.583 | 0.005 | Download |
| Daylight fingerprints | 0.700 | 0.000 | 0.712 | 0.003 | 0.706 | 0.005 | 0.701 | 0.003 | 0.760 | 0.000 | 0.410 | 0.000 | Download |
| ECFP2 fingerprints | 0.940 | 0.000 | 0.860 | 0.000 | 0.900 | 0.000 | 0.905 | 0.005 | 0.960 | 0.000 | 0.805 | 0.005 | Download |
| ECFP4 fingerprints | 0.950 | 0.000 | 0.910 | 0.005 | 0.930 | 0.000 | 0.930 | 0.000 | 0.970 | 0.000 | 0.859 | 0.003 | Download |
| ECFP6 fingerprints | 0.920 | 0.000 | 0.932 | 0.003 | 0.926 | 0.005 | 0.926 | 0.005 | 0.970 | 0.000 | 0.851 | 0.003 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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