Target name

P14842: 5-hydroxytryptamine receptor 2A


  Protein function

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca(2+) ions from intracellular stores. Affects neural activity, perception, cognition and mood. Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction.

  Database links

Uniprot primary ID P14842
PDB ID 4OAJ
DrugBank ID
BioGrid ID 248227
GuidetoPHARMACOLOGY ID 6
PharmGKB ID
KEGG ID rno:29595
DIP ID DIP-57661N
STRING ID 10116.ENSRNOP00000013408
IntAct ID P14842
DMDM
BRENDA
Reactome R-RNO-390666 R-RNO-416476
SignaLink
BioCyc
Entrez Gene (Gene ID) 29595
BindingDB P14842

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.880 0.000 0.760 0.004 0.820 0.000 0.830 0.000 0.900 0.000 0.647 0.005 Download
Estate fingerprints 0.821 0.006 0.745 0.003 0.783 0.005 0.790 0.000 0.860 0.000 0.568 0.004 Download
MACCS fingerprints 0.842 0.004 0.738 0.000 0.790 0.000 0.800 0.000 0.860 0.000 0.583 0.005 Download
Daylight fingerprints 0.700 0.000 0.712 0.003 0.706 0.005 0.701 0.003 0.760 0.000 0.410 0.000 Download
ECFP2 fingerprints 0.940 0.000 0.860 0.000 0.900 0.000 0.905 0.005 0.960 0.000 0.805 0.005 Download
ECFP4 fingerprints 0.950 0.000 0.910 0.005 0.930 0.000 0.930 0.000 0.970 0.000 0.859 0.003 Download
ECFP6 fingerprints 0.920 0.000 0.932 0.003 0.926 0.005 0.926 0.005 0.970 0.000 0.851 0.003 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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