Target name

P15056: Serine/threonine-protein kinase B-raf


  Protein function

Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May play a role in the postsynaptic responses of hippocampal neuron. Phosphorylates MAP2K1, and thereby contributes to the MAP kinase signal transduction pathway.

  Database links

Uniprot primary ID P15056
PDB ID 4KSP 3IDP 4EHG 2L05 3Q96 1UWH 4DBN 3PRI 4KSQ 3PRF 3II5 3PPJ 3NY5 4H58 3C4C 2FB8 3PPK 4PP7 4EHE 5CT7 4E26 4FK3 4JVG 5C9C 1UWJ 3Q4C 3TV6 3PSD 4MBJ 3PSB 4E4X 3TV4 3OG7 4G9R 4FC0 4MNF 4MNE 3SKC 4WO5 3D4Q 4G9C
DrugBank ID DB00398 DB08881 DB08912 DB08896
BioGrid ID 107141
GuidetoPHARMACOLOGY ID 1943
PharmGKB ID PA25408
KEGG ID hsa:673
DIP ID DIP-1045N
STRING ID 9606.ENSP00000288602
IntAct ID P15056
DMDM 50403720
BRENDA 2.7.10.2
Reactome R-HSA-5675221 R-HSA-1295596 R-HSA-187706 R-HSA-170968 R-HSA-5674135 R-HSA-170984 R-HSA-5674499 R-HSA-442742 R-HSA-5673000
SignaLink P15056
BioCyc
Entrez Gene (Gene ID) 673
BindingDB P15056

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.848 0.004 0.912 0.005 0.880 0.000 0.879 0.003 0.940 0.000 0.764 0.005 Download
Estate fingerprints 0.871 0.003 0.763 0.008 0.817 0.005 0.825 0.005 0.880 0.000 0.636 0.008 Download
MACCS fingerprints 0.891 0.003 0.809 0.005 0.850 0.000 0.859 0.003 0.901 0.003 0.704 0.005 Download
Daylight fingerprints 0.753 0.008 0.865 0.005 0.809 0.003 0.797 0.005 0.870 0.000 0.622 0.008 Download
ECFP2 fingerprints 0.955 0.005 0.885 0.004 0.920 0.000 0.920 0.000 0.980 0.000 0.839 0.003 Download
ECFP4 fingerprints 0.930 0.000 0.950 0.004 0.940 0.000 0.940 0.000 0.980 0.000 0.886 0.005 Download
ECFP6 fingerprints 0.892 0.004 0.988 0.005 0.940 0.000 0.939 0.003 0.986 0.005 0.886 0.005 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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 E-mail: biomed@csu.edu.cn