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E-mail: biomed@csu.edu.cn
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Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May play a role in the postsynaptic responses of hippocampal neuron. Phosphorylates MAP2K1, and thereby contributes to the MAP kinase signal transduction pathway.
| Uniprot primary ID | P15056 |
| PDB ID | 4KSP 3IDP 4EHG 2L05 3Q96 1UWH 4DBN 3PRI 4KSQ 3PRF 3II5 3PPJ 3NY5 4H58 3C4C 2FB8 3PPK 4PP7 4EHE 5CT7 4E26 4FK3 4JVG 5C9C 1UWJ 3Q4C 3TV6 3PSD 4MBJ 3PSB 4E4X 3TV4 3OG7 4G9R 4FC0 4MNF 4MNE 3SKC 4WO5 3D4Q 4G9C |
| DrugBank ID | DB00398 DB08881 DB08912 DB08896 |
| BioGrid ID | 107141 |
| GuidetoPHARMACOLOGY ID | 1943 |
| PharmGKB ID | PA25408 |
| KEGG ID | hsa:673 |
| DIP ID | DIP-1045N |
| STRING ID | 9606.ENSP00000288602 |
| IntAct ID | P15056 |
| DMDM | 50403720 |
| BRENDA | 2.7.10.2 |
| Reactome | R-HSA-5675221 R-HSA-1295596 R-HSA-187706 R-HSA-170968 R-HSA-5674135 R-HSA-170984 R-HSA-5674499 R-HSA-442742 R-HSA-5673000 |
| SignaLink | P15056 |
| BioCyc | |
| Entrez Gene (Gene ID) | 673 |
| BindingDB | P15056 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.848 | 0.004 | 0.912 | 0.005 | 0.880 | 0.000 | 0.879 | 0.003 | 0.940 | 0.000 | 0.764 | 0.005 | Download |
| Estate fingerprints | 0.871 | 0.003 | 0.763 | 0.008 | 0.817 | 0.005 | 0.825 | 0.005 | 0.880 | 0.000 | 0.636 | 0.008 | Download |
| MACCS fingerprints | 0.891 | 0.003 | 0.809 | 0.005 | 0.850 | 0.000 | 0.859 | 0.003 | 0.901 | 0.003 | 0.704 | 0.005 | Download |
| Daylight fingerprints | 0.753 | 0.008 | 0.865 | 0.005 | 0.809 | 0.003 | 0.797 | 0.005 | 0.870 | 0.000 | 0.622 | 0.008 | Download |
| ECFP2 fingerprints | 0.955 | 0.005 | 0.885 | 0.004 | 0.920 | 0.000 | 0.920 | 0.000 | 0.980 | 0.000 | 0.839 | 0.003 | Download |
| ECFP4 fingerprints | 0.930 | 0.000 | 0.950 | 0.004 | 0.940 | 0.000 | 0.940 | 0.000 | 0.980 | 0.000 | 0.886 | 0.005 | Download |
| ECFP6 fingerprints | 0.892 | 0.004 | 0.988 | 0.005 | 0.940 | 0.000 | 0.939 | 0.003 | 0.986 | 0.005 | 0.886 | 0.005 | Download |
| Positive dataset | Negative dataset |
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E-mail: biomed@csu.edu.cn
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