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E-mail: biomed@csu.edu.cn
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Broad specificity aminopeptidase. Plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. May play a critical role in the pathogenesis of cholesterol gallstone disease. May be involved in the metabolism of regulatory peptides of diverse cell types, responsible for the processing of peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. Found to cleave antigen peptides bound to major histocompatibility complex class II molecules of presenting cells and to degrade neurotransmitters at synaptic junctions. Is also implicated as a regulator of IL-8 bioavailability in the endometrium, and therefore may contribute to the regulation of angiogenesis. Is used as a marker for acute myeloid leukemia and plays a role in tumor invasion. In case of human coronavirus 229E (HCoV-229E) infection, serves as receptor for HCoV-229E spike glycoprotein. Mediates as well human cytomegalovirus (HCMV) infection.
| Uniprot primary ID | P15144 |
| PDB ID | 4FYQ 4FYS 4FYR 4FYT |
| DrugBank ID | DB00973 DB06196 |
| BioGrid ID | 106787 |
| GuidetoPHARMACOLOGY ID | 1560 |
| PharmGKB ID | PA24815 |
| KEGG ID | hsa:290 |
| DIP ID | |
| STRING ID | 9606.ENSP00000300060 |
| IntAct ID | P15144 |
| DMDM | 143811362 |
| BRENDA | 3.4.11.2 |
| Reactome | R-HSA-2022377 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 290 |
| BindingDB | P15144 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.930 | 0.000 | 0.874 | 0.004 | 0.902 | 0.004 | 0.903 | 0.005 | 0.966 | 0.005 | 0.802 | 0.006 | Download |
| Estate fingerprints | 0.934 | 0.005 | 0.930 | 0.003 | 0.932 | 0.004 | 0.932 | 0.004 | 0.970 | 0.000 | 0.864 | 0.005 | Download |
| MACCS fingerprints | 0.914 | 0.007 | 0.922 | 0.005 | 0.918 | 0.004 | 0.918 | 0.004 | 0.980 | 0.000 | 0.837 | 0.007 | Download |
| Daylight fingerprints | 0.891 | 0.017 | 0.781 | 0.000 | 0.836 | 0.007 | 0.845 | 0.010 | 0.867 | 0.005 | 0.675 | 0.014 | Download |
| ECFP2 fingerprints | 0.954 | 0.005 | 0.952 | 0.004 | 0.953 | 0.005 | 0.953 | 0.005 | 0.986 | 0.005 | 0.903 | 0.005 | Download |
| ECFP4 fingerprints | 0.967 | 0.005 | 0.965 | 0.000 | 0.966 | 0.005 | 0.966 | 0.005 | 0.989 | 0.003 | 0.928 | 0.006 | Download |
| ECFP6 fingerprints | 0.964 | 0.005 | 0.956 | 0.000 | 0.960 | 0.000 | 0.960 | 0.000 | 0.989 | 0.003 | 0.923 | 0.007 | Download |
| Positive dataset | Negative dataset |
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E-mail: biomed@csu.edu.cn
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