Target name

P15144: Aminopeptidase N


  Protein function

Broad specificity aminopeptidase. Plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. May play a critical role in the pathogenesis of cholesterol gallstone disease. May be involved in the metabolism of regulatory peptides of diverse cell types, responsible for the processing of peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. Found to cleave antigen peptides bound to major histocompatibility complex class II molecules of presenting cells and to degrade neurotransmitters at synaptic junctions. Is also implicated as a regulator of IL-8 bioavailability in the endometrium, and therefore may contribute to the regulation of angiogenesis. Is used as a marker for acute myeloid leukemia and plays a role in tumor invasion. In case of human coronavirus 229E (HCoV-229E) infection, serves as receptor for HCoV-229E spike glycoprotein. Mediates as well human cytomegalovirus (HCMV) infection.

  Database links

Uniprot primary ID P15144
PDB ID 4FYQ 4FYS 4FYR 4FYT
DrugBank ID DB00973 DB06196
BioGrid ID 106787
GuidetoPHARMACOLOGY ID 1560
PharmGKB ID PA24815
KEGG ID hsa:290
DIP ID
STRING ID 9606.ENSP00000300060
IntAct ID P15144
DMDM 143811362
BRENDA 3.4.11.2
Reactome R-HSA-2022377
SignaLink
BioCyc
Entrez Gene (Gene ID) 290
BindingDB P15144

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.930 0.000 0.874 0.004 0.902 0.004 0.903 0.005 0.966 0.005 0.802 0.006 Download
Estate fingerprints 0.934 0.005 0.930 0.003 0.932 0.004 0.932 0.004 0.970 0.000 0.864 0.005 Download
MACCS fingerprints 0.914 0.007 0.922 0.005 0.918 0.004 0.918 0.004 0.980 0.000 0.837 0.007 Download
Daylight fingerprints 0.891 0.017 0.781 0.000 0.836 0.007 0.845 0.010 0.867 0.005 0.675 0.014 Download
ECFP2 fingerprints 0.954 0.005 0.952 0.004 0.953 0.005 0.953 0.005 0.986 0.005 0.903 0.005 Download
ECFP4 fingerprints 0.967 0.005 0.965 0.000 0.966 0.005 0.966 0.005 0.989 0.003 0.928 0.006 Download
ECFP6 fingerprints 0.964 0.005 0.956 0.000 0.960 0.000 0.960 0.000 0.989 0.003 0.923 0.007 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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