Target name

P17706: Tyrosine-protein phosphatase non-receptor type 2


  Protein function

Non-receptor type tyrosine-specific phosphatase that dephosphorylates receptor protein tyrosine kinases including INSR, EGFR, CSF1R, PDGFR. Also dephosphorylates non-receptor protein tyrosine kinases like JAK1, JAK2, JAK3, Src family kinases, STAT1, STAT3, STAT5A, STAT5B and STAT6 either in the nucleus or the cytoplasm. Negatively regulates numerous signaling pathways and biological processes like hematopoiesis, inflammatory response, cell proliferation and differentiation, and glucose homeostasis. Plays a multifaceted and important role in the development of the immune system. Functions in T-cell receptor signaling through dephosphorylation of FYN and LCK to control T-cells differentiation and activation. Dephosphorylates CSF1R, negatively regulating its downstream signaling and macrophage differentiation. Negatively regulates cytokine (IL2/interleukin-2 and interferon)-mediated signaling through dephosphorylation of the cytoplasmic kinases JAK1, JAK3 and their substrate STAT1, that propagate signaling downstream of the cytokine receptors. Also regulates the IL6/interleukin-6 and IL4/interleukin-4 cytokine signaling through dephosphorylation of STAT3 and STAT6 respectively. In addition to the immune system, it is involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth. Activated by the integrin ITGA1/ITGB1, it dephosphorylates EGFR and negatively regulates EGF signaling. Dephosphorylates PDGFRB and negatively regulates platelet-derived growth factor receptor-beta signaling pathway and therefore cell proliferation. Negatively regulates tumor necrosis factor-mediated signaling downstream via MAPK through SRC dephosphorylation. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of the hepatocyte growth factor receptor MET. Plays also an important role in glucose homeostasis. For instance, negatively regulates the insulin receptor signaling pathway through the dephosphorylation of INSR and control gluconeogenesis and liver glucose production through negative regulation of the IL6 signaling pathways. Finally, it negatively regulates prolactin-mediated signaling pathway through dephosphorylation of STAT5A and STAT5B. May also bind DNA.

  Database links

Uniprot primary ID P17706
PDB ID 1L8K
DrugBank ID
BioGrid ID 111737
GuidetoPHARMACOLOGY ID
PharmGKB ID PA33993
KEGG ID hsa:5771
DIP ID
STRING ID 9606.ENSP00000311857
IntAct ID P17706
DMDM 229462762
BRENDA 3.1.3.48
Reactome R-HSA-877312
SignaLink P17706
BioCyc
Entrez Gene (Gene ID) 5771
BindingDB P17706

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.923 0.005 0.893 0.005 0.908 0.004 0.909 0.003 0.970 0.000 0.816 0.007 Download
Estate fingerprints 0.907 0.005 0.801 0.003 0.854 0.005 0.862 0.004 0.920 0.000 0.714 0.005 Download
MACCS fingerprints 0.914 0.005 0.810 0.003 0.862 0.004 0.869 0.003 0.929 0.003 0.729 0.007 Download
Daylight fingerprints 0.841 0.009 0.945 0.007 0.893 0.005 0.887 0.005 0.969 0.003 0.790 0.008 Download
ECFP2 fingerprints 0.948 0.004 0.938 0.004 0.943 0.005 0.943 0.005 0.990 0.000 0.885 0.008 Download
ECFP4 fingerprints 0.912 0.004 0.986 0.004 0.949 0.003 0.944 0.005 0.990 0.000 0.896 0.005 Download
ECFP6 fingerprints 0.891 0.003 1.000 0.000 0.947 0.005 0.941 0.003 0.990 0.000 0.897 0.005 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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