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E-mail: biomed@csu.edu.cn
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Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET.
| Uniprot primary ID | P18031 |
| PDB ID | 1NWE 1I57 1NNY 1NWL 1Q1M 3I7Z 1T4J 2QBQ 2QBP 2QBS 2QBR 1A5Y 1OEV 2VEY 2VEW 2VEV 2VEU 4I8N 2F71 2F70 1OEU 1OET 1OES 1LQF 3ZV2 3I80 1PA1 1OEO 1OEM 2HB1 1PXH 1PTV 1PTU 1PTT 1PTY 1C88 1G7G 1G7F 2B07 3CWE 3ZMQ 1NO6 1T49 1ONZ 4QAP 3QKQ 3QKP 1ONY 1JF7 1WAX 4QAH |
| DrugBank ID | DB01133 |
| BioGrid ID | 111736 |
| GuidetoPHARMACOLOGY ID | |
| PharmGKB ID | PA33985 |
| KEGG ID | hsa:5770 |
| DIP ID | DIP-38014N |
| STRING ID | 9606.ENSP00000360683 |
| IntAct ID | P18031 |
| DMDM | 131467 |
| BRENDA | 3.1.3.48 |
| Reactome | R-HSA-877312 R-HSA-912694 R-HSA-354192 R-HSA-982772 |
| SignaLink | P18031 |
| BioCyc | |
| Entrez Gene (Gene ID) | 5770 |
| BindingDB | P18031 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.911 | 0.003 | 0.881 | 0.003 | 0.896 | 0.005 | 0.898 | 0.004 | 0.960 | 0.000 | 0.791 | 0.003 | Download |
| Estate fingerprints | 0.840 | 0.005 | 0.792 | 0.000 | 0.816 | 0.005 | 0.820 | 0.000 | 0.880 | 0.000 | 0.631 | 0.006 | Download |
| MACCS fingerprints | 0.840 | 0.000 | 0.820 | 0.000 | 0.830 | 0.000 | 0.830 | 0.000 | 0.910 | 0.000 | 0.654 | 0.005 | Download |
| Daylight fingerprints | 0.831 | 0.003 | 0.799 | 0.004 | 0.815 | 0.005 | 0.820 | 0.000 | 0.861 | 0.003 | 0.629 | 0.003 | Download |
| ECFP2 fingerprints | 0.944 | 0.005 | 0.888 | 0.005 | 0.916 | 0.005 | 0.920 | 0.000 | 0.979 | 0.003 | 0.831 | 0.003 | Download |
| ECFP4 fingerprints | 0.894 | 0.005 | 0.936 | 0.005 | 0.915 | 0.005 | 0.911 | 0.003 | 0.980 | 0.000 | 0.831 | 0.003 | Download |
| ECFP6 fingerprints | 0.839 | 0.003 | 0.961 | 0.005 | 0.900 | 0.000 | 0.894 | 0.005 | 0.970 | 0.000 | 0.807 | 0.005 | Download |
| Positive dataset | Negative dataset |
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E-mail: biomed@csu.edu.cn
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