Target name

P18031: Tyrosine-protein phosphatase non-receptor type 1


  Protein function

Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET.

  Database links

Uniprot primary ID P18031
PDB ID 1NWE 1I57 1NNY 1NWL 1Q1M 3I7Z 1T4J 2QBQ 2QBP 2QBS 2QBR 1A5Y 1OEV 2VEY 2VEW 2VEV 2VEU 4I8N 2F71 2F70 1OEU 1OET 1OES 1LQF 3ZV2 3I80 1PA1 1OEO 1OEM 2HB1 1PXH 1PTV 1PTU 1PTT 1PTY 1C88 1G7G 1G7F 2B07 3CWE 3ZMQ 1NO6 1T49 1ONZ 4QAP 3QKQ 3QKP 1ONY 1JF7 1WAX 4QAH
DrugBank ID DB01133
BioGrid ID 111736
GuidetoPHARMACOLOGY ID
PharmGKB ID PA33985
KEGG ID hsa:5770
DIP ID DIP-38014N
STRING ID 9606.ENSP00000360683
IntAct ID P18031
DMDM 131467
BRENDA 3.1.3.48
Reactome R-HSA-877312 R-HSA-912694 R-HSA-354192 R-HSA-982772
SignaLink P18031
BioCyc
Entrez Gene (Gene ID) 5770
BindingDB P18031

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.911 0.003 0.881 0.003 0.896 0.005 0.898 0.004 0.960 0.000 0.791 0.003 Download
Estate fingerprints 0.840 0.005 0.792 0.000 0.816 0.005 0.820 0.000 0.880 0.000 0.631 0.006 Download
MACCS fingerprints 0.840 0.000 0.820 0.000 0.830 0.000 0.830 0.000 0.910 0.000 0.654 0.005 Download
Daylight fingerprints 0.831 0.003 0.799 0.004 0.815 0.005 0.820 0.000 0.861 0.003 0.629 0.003 Download
ECFP2 fingerprints 0.944 0.005 0.888 0.005 0.916 0.005 0.920 0.000 0.979 0.003 0.831 0.003 Download
ECFP4 fingerprints 0.894 0.005 0.936 0.005 0.915 0.005 0.911 0.003 0.980 0.000 0.831 0.003 Download
ECFP6 fingerprints 0.839 0.003 0.961 0.005 0.900 0.000 0.894 0.005 0.970 0.000 0.807 0.005 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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