Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. May play a role in innate immunity.
| Uniprot primary ID | P20231 |
| PDB ID | 2BM2 2FWW 2FPZ 1AAO 2GDD 2FS9 2ZA5 2FXR 1A0L 3V7T 2FS8 |
| DrugBank ID | |
| BioGrid ID | 113029;122201 |
| GuidetoPHARMACOLOGY ID | |
| PharmGKB ID | PA36698 |
| KEGG ID | hsa:64499 hsa:7177 |
| DIP ID | |
| STRING ID | 9606.ENSP00000343577 |
| IntAct ID | P20231 |
| DMDM | 116242830 |
| BRENDA | 3.4.21.59 |
| Reactome | |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 7177;64499 |
| BindingDB | P20231 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.815 | 0.017 | 0.921 | 0.011 | 0.868 | 0.013 | 0.862 | 0.015 | 0.949 | 0.003 | 0.742 | 0.023 | Download |
| Estate fingerprints | 0.979 | 0.003 | 0.927 | 0.000 | 0.953 | 0.005 | 0.959 | 0.003 | 0.980 | 0.000 | 0.909 | 0.003 | Download |
| MACCS fingerprints | 0.871 | 0.014 | 0.919 | 0.008 | 0.895 | 0.007 | 0.892 | 0.009 | 0.965 | 0.005 | 0.793 | 0.013 | Download |
| Daylight fingerprints | 0.772 | 0.009 | 0.860 | 0.005 | 0.816 | 0.005 | 0.808 | 0.008 | 0.900 | 0.007 | 0.633 | 0.013 | Download |
| ECFP2 fingerprints | 0.990 | 0.000 | 0.944 | 0.005 | 0.967 | 0.005 | 0.967 | 0.005 | 0.990 | 0.000 | 0.934 | 0.005 | Download |
| ECFP4 fingerprints | 0.990 | 0.000 | 0.958 | 0.006 | 0.974 | 0.005 | 0.974 | 0.005 | 0.999 | 0.003 | 0.951 | 0.006 | Download |
| ECFP6 fingerprints | 0.986 | 0.005 | 0.986 | 0.000 | 0.986 | 0.005 | 0.986 | 0.005 | 1.000 | 0.000 | 0.971 | 0.006 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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