Target name

P20231: Tryptase beta-2


  Protein function

Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. May play a role in innate immunity.

  Database links

Uniprot primary ID P20231
PDB ID 2BM2 2FWW 2FPZ 1AAO 2GDD 2FS9 2ZA5 2FXR 1A0L 3V7T 2FS8
DrugBank ID
BioGrid ID 113029;122201
GuidetoPHARMACOLOGY ID
PharmGKB ID PA36698
KEGG ID hsa:64499 hsa:7177
DIP ID
STRING ID 9606.ENSP00000343577
IntAct ID P20231
DMDM 116242830
BRENDA 3.4.21.59
Reactome
SignaLink
BioCyc
Entrez Gene (Gene ID) 7177;64499
BindingDB P20231

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.815 0.017 0.921 0.011 0.868 0.013 0.862 0.015 0.949 0.003 0.742 0.023 Download
Estate fingerprints 0.979 0.003 0.927 0.000 0.953 0.005 0.959 0.003 0.980 0.000 0.909 0.003 Download
MACCS fingerprints 0.871 0.014 0.919 0.008 0.895 0.007 0.892 0.009 0.965 0.005 0.793 0.013 Download
Daylight fingerprints 0.772 0.009 0.860 0.005 0.816 0.005 0.808 0.008 0.900 0.007 0.633 0.013 Download
ECFP2 fingerprints 0.990 0.000 0.944 0.005 0.967 0.005 0.967 0.005 0.990 0.000 0.934 0.005 Download
ECFP4 fingerprints 0.990 0.000 0.958 0.006 0.974 0.005 0.974 0.005 0.999 0.003 0.951 0.006 Download
ECFP6 fingerprints 0.986 0.005 0.986 0.000 0.986 0.005 0.986 0.005 1.000 0.000 0.971 0.006 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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