Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor for anandamide. Inhibits L-type Ca(2+) channel current.
| Uniprot primary ID | P20272 |
| PDB ID | |
| DrugBank ID | |
| BioGrid ID | 247288 |
| GuidetoPHARMACOLOGY ID | 56 |
| PharmGKB ID | |
| KEGG ID | rno:25248 |
| DIP ID | |
| STRING ID | 10116.ENSRNOP00000010850 |
| IntAct ID | P20272 |
| DMDM | |
| BRENDA | |
| Reactome | R-RNO-418594 R-RNO-373076 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 25248 |
| BindingDB | P20272 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.578 | 0.004 | 0.978 | 0.005 | 0.778 | 0.004 | 0.720 | 0.000 | 0.930 | 0.000 | 0.601 | 0.003 | Download |
| Estate fingerprints | 0.797 | 0.005 | 0.805 | 0.003 | 0.801 | 0.003 | 0.800 | 0.000 | 0.870 | 0.000 | 0.604 | 0.005 | Download |
| MACCS fingerprints | 0.842 | 0.004 | 0.758 | 0.004 | 0.800 | 0.000 | 0.810 | 0.000 | 0.880 | 0.000 | 0.600 | 0.000 | Download |
| Daylight fingerprints | 0.669 | 0.003 | 0.829 | 0.000 | 0.749 | 0.003 | 0.723 | 0.005 | 0.750 | 0.000 | 0.499 | 0.003 | Download |
| ECFP2 fingerprints | 0.908 | 0.004 | 0.952 | 0.004 | 0.930 | 0.000 | 0.927 | 0.005 | 0.980 | 0.000 | 0.854 | 0.005 | Download |
| ECFP4 fingerprints | 0.910 | 0.000 | 0.990 | 0.000 | 0.950 | 0.000 | 0.950 | 0.000 | 0.981 | 0.003 | 0.900 | 0.000 | Download |
| ECFP6 fingerprints | 0.870 | 0.000 | 0.990 | 0.000 | 0.930 | 0.000 | 0.923 | 0.005 | 0.980 | 0.000 | 0.863 | 0.005 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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