Target name

P20272: Cannabinoid receptor 1


  Protein function

Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor for anandamide. Inhibits L-type Ca(2+) channel current.

  Database links

Uniprot primary ID P20272
PDB ID
DrugBank ID
BioGrid ID 247288
GuidetoPHARMACOLOGY ID 56
PharmGKB ID
KEGG ID rno:25248
DIP ID
STRING ID 10116.ENSRNOP00000010850
IntAct ID P20272
DMDM
BRENDA
Reactome R-RNO-418594 R-RNO-373076
SignaLink
BioCyc
Entrez Gene (Gene ID) 25248
BindingDB P20272

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.578 0.004 0.978 0.005 0.778 0.004 0.720 0.000 0.930 0.000 0.601 0.003 Download
Estate fingerprints 0.797 0.005 0.805 0.003 0.801 0.003 0.800 0.000 0.870 0.000 0.604 0.005 Download
MACCS fingerprints 0.842 0.004 0.758 0.004 0.800 0.000 0.810 0.000 0.880 0.000 0.600 0.000 Download
Daylight fingerprints 0.669 0.003 0.829 0.000 0.749 0.003 0.723 0.005 0.750 0.000 0.499 0.003 Download
ECFP2 fingerprints 0.908 0.004 0.952 0.004 0.930 0.000 0.927 0.005 0.980 0.000 0.854 0.005 Download
ECFP4 fingerprints 0.910 0.000 0.990 0.000 0.950 0.000 0.950 0.000 0.981 0.003 0.900 0.000 Download
ECFP6 fingerprints 0.870 0.000 0.990 0.000 0.930 0.000 0.923 0.005 0.980 0.000 0.863 0.005 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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