Target name

P20648: Potassium-transporting ATPase alpha chain 1


  Protein function

Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for acid production in the stomach.

  Database links

Uniprot primary ID P20648
PDB ID
DrugBank ID DB00448 DB00213 DB01129 DB00736 DB00338
BioGrid ID 106985
GuidetoPHARMACOLOGY ID 849
PharmGKB ID PA25113
KEGG ID hsa:495
DIP ID
STRING ID 9606.ENSP00000262623
IntAct ID
DMDM 148877240
BRENDA 3.6.3.10
Reactome R-HSA-936837
SignaLink
BioCyc MetaCyc:HS02790-MONOMER
Entrez Gene (Gene ID) 495
BindingDB P20648

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.892 0.009 0.972 0.004 0.932 0.004 0.931 0.006 0.987 0.005 0.870 0.009 Download
Estate fingerprints 0.930 0.000 0.870 0.008 0.900 0.000 0.902 0.004 0.960 0.000 0.805 0.007 Download
MACCS fingerprints 0.828 0.004 0.920 0.006 0.874 0.008 0.867 0.005 0.951 0.003 0.747 0.011 Download
Daylight fingerprints 0.815 0.008 0.819 0.008 0.817 0.007 0.817 0.007 0.897 0.007 0.633 0.011 Download
ECFP2 fingerprints 0.960 0.000 0.936 0.003 0.948 0.004 0.948 0.004 0.988 0.004 0.893 0.007 Download
ECFP4 fingerprints 0.970 0.008 0.958 0.006 0.964 0.005 0.964 0.005 0.990 0.000 0.929 0.007 Download
ECFP6 fingerprints 0.962 0.008 0.972 0.003 0.967 0.005 0.967 0.005 0.990 0.000 0.932 0.008 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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