Target name

P21397: Amine oxidase [flavin-containing] A


  Protein function

Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine.

  Database links

Uniprot primary ID P21397
PDB ID 2BXR 2BXS 1H8Q 2Z5Y 2Z5X
DrugBank ID DB00953 DB00952 DB00752 DB01626 DB08804 DB00614 DB01104
BioGrid ID 110301
GuidetoPHARMACOLOGY ID 2489
PharmGKB ID PA236
KEGG ID hsa:4128
DIP ID
STRING ID 9606.ENSP00000340684
IntAct ID P21397
DMDM 113978
BRENDA 1.4.3.4
Reactome R-HSA-181430 R-HSA-380612 R-HSA-379397 R-HSA-379398 R-HSA-5579012 R-HSA-141333
SignaLink
BioCyc MetaCyc:HS01798-MONOMER
Entrez Gene (Gene ID) 4128
BindingDB P21397

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.818 0.004 0.880 0.000 0.849 0.003 0.844 0.005 0.931 0.003 0.698 0.004 Download
Estate fingerprints 0.825 0.005 0.793 0.005 0.809 0.003 0.815 0.005 0.880 0.000 0.621 0.006 Download
MACCS fingerprints 0.859 0.003 0.781 0.005 0.820 0.000 0.830 0.000 0.890 0.000 0.641 0.003 Download
Daylight fingerprints 0.756 0.005 0.784 0.000 0.770 0.000 0.767 0.005 0.810 0.000 0.539 0.003 Download
ECFP2 fingerprints 0.955 0.005 0.869 0.000 0.912 0.004 0.919 0.003 0.970 0.000 0.831 0.006 Download
ECFP4 fingerprints 0.964 0.005 0.910 0.006 0.937 0.005 0.938 0.004 0.980 0.000 0.876 0.010 Download
ECFP6 fingerprints 0.948 0.006 0.924 0.004 0.936 0.005 0.937 0.005 0.980 0.000 0.871 0.009 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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