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E-mail: biomed@csu.edu.cn
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Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C. Isoform 1 activates adenylyl cyclase. Isoform 2 inhibits adenylyl cyclase.
| Uniprot primary ID | P21731 |
| PDB ID | 1LBN |
| DrugBank ID | DB01207 |
| BioGrid ID | 112777 |
| GuidetoPHARMACOLOGY ID | 346 |
| PharmGKB ID | PA348 |
| KEGG ID | hsa:6915 |
| DIP ID | DIP-41465N |
| STRING ID | 9606.ENSP00000393333 |
| IntAct ID | P21731 |
| DMDM | 229463010 |
| BRENDA | |
| Reactome | R-HSA-391908 R-HSA-428930 R-HSA-416476 R-HSA-416482 |
| SignaLink | P21731 |
| BioCyc | |
| Entrez Gene (Gene ID) | 6915 |
| BindingDB | P21731 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.895 | 0.007 | 0.941 | 0.000 | 0.918 | 0.004 | 0.916 | 0.005 | 0.970 | 0.000 | 0.838 | 0.008 | Download |
| Estate fingerprints | 0.904 | 0.005 | 0.832 | 0.006 | 0.868 | 0.004 | 0.872 | 0.004 | 0.940 | 0.000 | 0.737 | 0.007 | Download |
| MACCS fingerprints | 0.856 | 0.005 | 0.854 | 0.000 | 0.855 | 0.005 | 0.855 | 0.005 | 0.930 | 0.000 | 0.707 | 0.007 | Download |
| Daylight fingerprints | 0.778 | 0.004 | 0.892 | 0.005 | 0.835 | 0.005 | 0.826 | 0.005 | 0.890 | 0.000 | 0.675 | 0.005 | Download |
| ECFP2 fingerprints | 0.941 | 0.003 | 0.965 | 0.005 | 0.953 | 0.005 | 0.952 | 0.004 | 0.990 | 0.000 | 0.911 | 0.003 | Download |
| ECFP4 fingerprints | 0.950 | 0.000 | 0.990 | 0.000 | 0.970 | 0.000 | 0.970 | 0.000 | 0.990 | 0.000 | 0.936 | 0.005 | Download |
| ECFP6 fingerprints | 0.939 | 0.003 | 0.989 | 0.000 | 0.964 | 0.005 | 0.960 | 0.000 | 0.990 | 0.000 | 0.930 | 0.000 | Download |
| Positive dataset | Negative dataset |
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E-mail: biomed@csu.edu.cn
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