Target name

P21731: Thromboxane A2 receptor


  Protein function

Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C. Isoform 1 activates adenylyl cyclase. Isoform 2 inhibits adenylyl cyclase.

  Database links

Uniprot primary ID P21731
PDB ID 1LBN
DrugBank ID DB01207
BioGrid ID 112777
GuidetoPHARMACOLOGY ID 346
PharmGKB ID PA348
KEGG ID hsa:6915
DIP ID DIP-41465N
STRING ID 9606.ENSP00000393333
IntAct ID P21731
DMDM 229463010
BRENDA
Reactome R-HSA-391908 R-HSA-428930 R-HSA-416476 R-HSA-416482
SignaLink P21731
BioCyc
Entrez Gene (Gene ID) 6915
BindingDB P21731

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.895 0.007 0.941 0.000 0.918 0.004 0.916 0.005 0.970 0.000 0.838 0.008 Download
Estate fingerprints 0.904 0.005 0.832 0.006 0.868 0.004 0.872 0.004 0.940 0.000 0.737 0.007 Download
MACCS fingerprints 0.856 0.005 0.854 0.000 0.855 0.005 0.855 0.005 0.930 0.000 0.707 0.007 Download
Daylight fingerprints 0.778 0.004 0.892 0.005 0.835 0.005 0.826 0.005 0.890 0.000 0.675 0.005 Download
ECFP2 fingerprints 0.941 0.003 0.965 0.005 0.953 0.005 0.952 0.004 0.990 0.000 0.911 0.003 Download
ECFP4 fingerprints 0.950 0.000 0.990 0.000 0.970 0.000 0.970 0.000 0.990 0.000 0.936 0.005 Download
ECFP6 fingerprints 0.939 0.003 0.989 0.000 0.964 0.005 0.960 0.000 0.990 0.000 0.930 0.000 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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