Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Its activity is mediated by G proteins which inhibit adenylyl cyclase. Modulates the circadian rhythm of contrast sensitivity by regulating the rhythmic expression of NPAS2 in the retinal ganglion cells (By similarity).
| Uniprot primary ID | P21917 |
| PDB ID | |
| DrugBank ID | DB00777 DB04908 DB04946 DB01238 DB01235 DB00734 DB00246 |
| BioGrid ID | 108149 |
| GuidetoPHARMACOLOGY ID | 217 |
| PharmGKB ID | PA27480 |
| KEGG ID | hsa:1815 |
| DIP ID | DIP-59865N |
| STRING ID | |
| IntAct ID | |
| DMDM | 1345939 |
| BRENDA | |
| Reactome | R-HSA-418594 R-HSA-390651 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 1815 |
| BindingDB | P21917 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.870 | 0.000 | 0.790 | 0.005 | 0.830 | 0.000 | 0.840 | 0.000 | 0.910 | 0.000 | 0.665 | 0.005 | Download |
| Estate fingerprints | 0.852 | 0.004 | 0.788 | 0.000 | 0.820 | 0.000 | 0.822 | 0.004 | 0.892 | 0.004 | 0.636 | 0.005 | Download |
| MACCS fingerprints | 0.910 | 0.000 | 0.770 | 0.005 | 0.840 | 0.000 | 0.850 | 0.000 | 0.910 | 0.000 | 0.681 | 0.003 | Download |
| Daylight fingerprints | 0.750 | 0.000 | 0.770 | 0.003 | 0.760 | 0.000 | 0.759 | 0.003 | 0.810 | 0.000 | 0.515 | 0.005 | Download |
| ECFP2 fingerprints | 0.936 | 0.005 | 0.876 | 0.004 | 0.906 | 0.005 | 0.910 | 0.000 | 0.960 | 0.000 | 0.810 | 0.000 | Download |
| ECFP4 fingerprints | 0.930 | 0.000 | 0.910 | 0.000 | 0.920 | 0.000 | 0.924 | 0.005 | 0.970 | 0.000 | 0.850 | 0.000 | Download |
| ECFP6 fingerprints | 0.890 | 0.000 | 0.930 | 0.005 | 0.910 | 0.000 | 0.910 | 0.000 | 0.970 | 0.000 | 0.830 | 0.000 | Download |
| Positive dataset | Negative dataset |
The recommended browsers: Safari, Firefox, Chrome, IE(Ver.>8).
E-mail: jiedong@csu.edu.cn
 |
 |
 |
 |
 |
 |