Target name

P21917: D(4) dopamine receptor


  Protein function

Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Its activity is mediated by G proteins which inhibit adenylyl cyclase. Modulates the circadian rhythm of contrast sensitivity by regulating the rhythmic expression of NPAS2 in the retinal ganglion cells (By similarity).

  Database links

Uniprot primary ID P21917
PDB ID
DrugBank ID DB00777 DB04908 DB04946 DB01238 DB01235 DB00734 DB00246
BioGrid ID 108149
GuidetoPHARMACOLOGY ID 217
PharmGKB ID PA27480
KEGG ID hsa:1815
DIP ID DIP-59865N
STRING ID
IntAct ID
DMDM 1345939
BRENDA
Reactome R-HSA-418594 R-HSA-390651
SignaLink
BioCyc
Entrez Gene (Gene ID) 1815
BindingDB P21917

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.870 0.000 0.790 0.005 0.830 0.000 0.840 0.000 0.910 0.000 0.665 0.005 Download
Estate fingerprints 0.852 0.004 0.788 0.000 0.820 0.000 0.822 0.004 0.892 0.004 0.636 0.005 Download
MACCS fingerprints 0.910 0.000 0.770 0.005 0.840 0.000 0.850 0.000 0.910 0.000 0.681 0.003 Download
Daylight fingerprints 0.750 0.000 0.770 0.003 0.760 0.000 0.759 0.003 0.810 0.000 0.515 0.005 Download
ECFP2 fingerprints 0.936 0.005 0.876 0.004 0.906 0.005 0.910 0.000 0.960 0.000 0.810 0.000 Download
ECFP4 fingerprints 0.930 0.000 0.910 0.000 0.920 0.000 0.924 0.005 0.970 0.000 0.850 0.000 Download
ECFP6 fingerprints 0.890 0.000 0.930 0.005 0.910 0.000 0.910 0.000 0.970 0.000 0.830 0.000 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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