TargetNet
  Target name

P27338: Amine oxidase [flavin-containing] B

  Protein function

Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine.

  Database links
Uniprot primary ID P27338
PDB ID 1OJC 2VZ2 3PO7 1S3E 1OJD 4A79 1OJA 2C75 2C76 2C70 2C72 2C73 1S3B 4CRT 2V5Z 1S2Q 1S2Y 1GOS 2XFO 2XFP 2XFQ 2BK3 2BK5 2XFU 2V60 2V61 2XFN 4A7A 1OJ9 2C67 2BYB 2C65 2C64 3ZYX 1H8R 2C66 2XCG 2VRM 2VRL 2BK4
DrugBank ID DB01363 DB03147 DB01367 DB01626 DB00780 DB00988 DB00601
BioGrid ID 110302
GuidetoPHARMACOLOGY ID 2490
PharmGKB ID PA237
KEGG ID hsa:4129
DIP ID
STRING ID 9606.ENSP00000367309
IntAct ID P27338
DMDM 113980
BRENDA 1.4.3.4
Reactome R-HSA-141333
SignaLink
BioCyc MetaCyc:HS00966-MONOMER
Entrez Gene (Gene ID) 4129
BindingDB P27338
  Model Performance Metrics
Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.878 0.004 0.904 0.000 0.891 0.003 0.890 0.000 0.951 0.003 0.786 0.005 Download
Estate fingerprints 0.822 0.004 0.838 0.000 0.830 0.000 0.828 0.004 0.900 0.000 0.658 0.006 Download
MACCS fingerprints 0.823 0.005 0.837 0.004 0.830 0.000 0.830 0.000 0.910 0.000 0.655 0.005 Download
Daylight fingerprints 0.720 0.000 0.820 0.000 0.770 0.000 0.757 0.005 0.840 0.000 0.539 0.003 Download
ECFP2 fingerprints 0.946 0.005 0.900 0.000 0.923 0.005 0.927 0.005 0.980 0.000 0.848 0.004 Download
ECFP4 fingerprints 0.961 0.003 0.941 0.000 0.951 0.003 0.952 0.004 0.990 0.000 0.904 0.005 Download
ECFP6 fingerprints 0.947 0.005 0.965 0.000 0.956 0.005 0.956 0.005 0.990 0.000 0.913 0.005 Download
  Download datasets
Positive dataset Negative dataset

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 E-mail: biomed@csu.edu.cn