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E-mail: biomed@csu.edu.cn
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G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca(2+) ions from intracellular stores. Affects neural activity, perception, cognition and mood. Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction.
| Uniprot primary ID | P28223 |
| PDB ID | |
| DrugBank ID | DB00751 DB00777 DB06148 DB01142 DB01049 DB01624 DB00246 |
| BioGrid ID | 109588 |
| GuidetoPHARMACOLOGY ID | 6 |
| PharmGKB ID | PA193 |
| KEGG ID | hsa:3356 |
| DIP ID | DIP-41844N |
| STRING ID | 9606.ENSP00000367959 |
| IntAct ID | |
| DMDM | 543727 |
| BRENDA | |
| Reactome | R-HSA-390666 R-HSA-416476 |
| SignaLink | P28223 |
| BioCyc | |
| Entrez Gene (Gene ID) | 3356 |
| BindingDB | P28223 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.842 | 0.004 | 0.778 | 0.005 | 0.810 | 0.000 | 0.814 | 0.005 | 0.880 | 0.000 | 0.620 | 0.005 | Download |
| Estate fingerprints | 0.800 | 0.000 | 0.680 | 0.005 | 0.740 | 0.000 | 0.750 | 0.000 | 0.807 | 0.005 | 0.480 | 0.000 | Download |
| MACCS fingerprints | 0.830 | 0.000 | 0.710 | 0.000 | 0.770 | 0.000 | 0.790 | 0.000 | 0.840 | 0.000 | 0.550 | 0.000 | Download |
| Daylight fingerprints | 0.690 | 0.000 | 0.730 | 0.000 | 0.710 | 0.000 | 0.700 | 0.000 | 0.760 | 0.000 | 0.420 | 0.000 | Download |
| ECFP2 fingerprints | 0.915 | 0.005 | 0.845 | 0.004 | 0.880 | 0.000 | 0.882 | 0.004 | 0.950 | 0.000 | 0.761 | 0.003 | Download |
| ECFP4 fingerprints | 0.880 | 0.000 | 0.912 | 0.000 | 0.896 | 0.005 | 0.891 | 0.003 | 0.960 | 0.000 | 0.791 | 0.003 | Download |
| ECFP6 fingerprints | 0.848 | 0.004 | 0.924 | 0.000 | 0.886 | 0.005 | 0.880 | 0.000 | 0.950 | 0.000 | 0.772 | 0.004 | Download |
| Positive dataset | Negative dataset |
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E-mail: biomed@csu.edu.cn
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