Target name

P28223: 5-hydroxytryptamine receptor 2A


  Protein function

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca(2+) ions from intracellular stores. Affects neural activity, perception, cognition and mood. Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction.

  Database links

Uniprot primary ID P28223
PDB ID
DrugBank ID DB00751 DB00777 DB06148 DB01142 DB01049 DB01624 DB00246
BioGrid ID 109588
GuidetoPHARMACOLOGY ID 6
PharmGKB ID PA193
KEGG ID hsa:3356
DIP ID DIP-41844N
STRING ID 9606.ENSP00000367959
IntAct ID
DMDM 543727
BRENDA
Reactome R-HSA-390666 R-HSA-416476
SignaLink P28223
BioCyc
Entrez Gene (Gene ID) 3356
BindingDB P28223

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.842 0.004 0.778 0.005 0.810 0.000 0.814 0.005 0.880 0.000 0.620 0.005 Download
Estate fingerprints 0.800 0.000 0.680 0.005 0.740 0.000 0.750 0.000 0.807 0.005 0.480 0.000 Download
MACCS fingerprints 0.830 0.000 0.710 0.000 0.770 0.000 0.790 0.000 0.840 0.000 0.550 0.000 Download
Daylight fingerprints 0.690 0.000 0.730 0.000 0.710 0.000 0.700 0.000 0.760 0.000 0.420 0.000 Download
ECFP2 fingerprints 0.915 0.005 0.845 0.004 0.880 0.000 0.882 0.004 0.950 0.000 0.761 0.003 Download
ECFP4 fingerprints 0.880 0.000 0.912 0.000 0.896 0.005 0.891 0.003 0.960 0.000 0.791 0.003 Download
ECFP6 fingerprints 0.848 0.004 0.924 0.000 0.886 0.005 0.880 0.000 0.950 0.000 0.772 0.004 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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 E-mail: biomed@csu.edu.cn