Target name

P28335: 5-hydroxytryptamine receptor 2C


  Protein function

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including ergot alkaloid derivatives, 1-2,5,-dimethoxy-4-iodophenyl-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores. Regulates neuronal activity via the activation of short transient receptor potential calcium channels in the brain, and thereby modulates the activation of pro-opiomelacortin neurons and the release of CRH that then regulates the release of corticosterone. Plays a role in the regulation of appetite and eating behavior, responses to anxiogenic stimuli and stress. Plays a role in insulin sensitivity and glucose homeostasis.

  Database links

Uniprot primary ID P28335
PDB ID
DrugBank ID DB00777 DB06148 DB01142 DB01049 DB00321 DB01149 DB00246
BioGrid ID 109590
GuidetoPHARMACOLOGY ID 8
PharmGKB ID PA194
KEGG ID hsa:3358
DIP ID
STRING ID 9606.ENSP00000276198
IntAct ID P28335
DMDM 112816
BRENDA
Reactome R-HSA-390666 R-HSA-416476
SignaLink P28335
BioCyc
Entrez Gene (Gene ID) 3358
BindingDB P28335

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.810 0.000 0.770 0.003 0.790 0.000 0.793 0.005 0.861 0.003 0.581 0.003 Download
Estate fingerprints 0.780 0.000 0.700 0.005 0.740 0.000 0.750 0.000 0.805 0.005 0.480 0.000 Download
MACCS fingerprints 0.798 0.004 0.702 0.000 0.750 0.000 0.760 0.000 0.820 0.000 0.501 0.003 Download
Daylight fingerprints 0.666 0.005 0.714 0.005 0.690 0.000 0.680 0.000 0.750 0.000 0.383 0.005 Download
ECFP2 fingerprints 0.891 0.003 0.829 0.000 0.860 0.000 0.869 0.003 0.940 0.000 0.729 0.003 Download
ECFP4 fingerprints 0.884 0.005 0.912 0.005 0.898 0.004 0.896 0.005 0.960 0.000 0.792 0.004 Download
ECFP6 fingerprints 0.859 0.003 0.919 0.003 0.889 0.003 0.888 0.004 0.960 0.000 0.779 0.003 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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