Target name

P30518: Vasopressin V2 receptor


  Protein function

Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption.

  Database links

Uniprot primary ID P30518
PDB ID 4JQI
DrugBank ID DB02638 DB06212 DB00035 DB00067 DB00872
BioGrid ID 107035
GuidetoPHARMACOLOGY ID 368
PharmGKB ID PA25189
KEGG ID hsa:554
DIP ID
STRING ID 9606.ENSP00000338072
IntAct ID
DMDM 267256
BRENDA
Reactome R-HSA-388479 R-HSA-432040 R-HSA-418555
SignaLink P30518
BioCyc
Entrez Gene (Gene ID) 554
BindingDB P30518

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.786 0.005 0.952 0.003 0.869 0.003 0.858 0.004 0.950 0.000 0.748 0.004 Download
Estate fingerprints 0.872 0.004 0.780 0.007 0.826 0.005 0.831 0.003 0.897 0.005 0.652 0.004 Download
MACCS fingerprints 0.820 0.000 0.840 0.003 0.830 0.000 0.829 0.003 0.930 0.000 0.663 0.007 Download
Daylight fingerprints 0.772 0.004 0.908 0.004 0.840 0.000 0.830 0.000 0.910 0.000 0.693 0.005 Download
ECFP2 fingerprints 0.906 0.005 0.968 0.004 0.937 0.005 0.934 0.005 0.980 0.000 0.874 0.005 Download
ECFP4 fingerprints 0.900 0.000 1.000 0.000 0.950 0.000 0.940 0.000 0.990 0.000 0.899 0.003 Download
ECFP6 fingerprints 0.878 0.006 1.000 0.000 0.939 0.003 0.934 0.005 0.990 0.000 0.883 0.005 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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