Target name

P31390: Histamine H1 receptor


  Protein function

In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system.

  Database links

Uniprot primary ID P31390
PDB ID
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID 262
PharmGKB ID
KEGG ID rno:24448
DIP ID
STRING ID 10116.ENSRNOP00000009775
IntAct ID
DMDM
BRENDA
Reactome
SignaLink
BioCyc
Entrez Gene (Gene ID) 24448
BindingDB P31390

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.806 0.005 0.928 0.011 0.867 0.008 0.857 0.008 0.921 0.003 0.737 0.014 Download
Estate fingerprints 0.807 0.009 0.799 0.012 0.803 0.009 0.803 0.009 0.891 0.003 0.605 0.019 Download
MACCS fingerprints 0.855 0.005 0.821 0.005 0.838 0.004 0.839 0.003 0.929 0.003 0.672 0.006 Download
Daylight fingerprints 0.759 0.006 0.793 0.007 0.776 0.005 0.771 0.003 0.831 0.003 0.550 0.007 Download
ECFP2 fingerprints 0.892 0.006 0.818 0.007 0.855 0.007 0.859 0.006 0.957 0.005 0.712 0.009 Download
ECFP4 fingerprints 0.902 0.006 0.890 0.005 0.896 0.005 0.899 0.003 0.970 0.000 0.797 0.009 Download
ECFP6 fingerprints 0.874 0.007 0.930 0.006 0.902 0.008 0.899 0.006 0.960 0.000 0.806 0.012 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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