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E-mail: biomed@csu.edu.cn
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Receptor for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. It is functionally coupled not only to inhibition of adenylate cyclase, but also to activation of both arachidonate release and mitogen-activated protein (MAP) kinase cascade. Mediates antiproliferative action of somatostatin in tumor cells.
| Uniprot primary ID | P31391 |
| PDB ID | |
| DrugBank ID | |
| BioGrid ID | 112632 |
| GuidetoPHARMACOLOGY ID | 358 |
| PharmGKB ID | PA36157 |
| KEGG ID | hsa:6754 |
| DIP ID | |
| STRING ID | 9606.ENSP00000255008 |
| IntAct ID | |
| DMDM | 206729897 |
| BRENDA | |
| Reactome | R-HSA-418594 R-HSA-375276 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 6754 |
| BindingDB |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.830 | 0.000 | 0.970 | 0.000 | 0.900 | 0.000 | 0.890 | 0.000 | 0.970 | 0.000 | 0.810 | 0.000 | Download |
| Estate fingerprints | 0.860 | 0.000 | 0.960 | 0.000 | 0.910 | 0.000 | 0.908 | 0.004 | 0.970 | 0.000 | 0.823 | 0.005 | Download |
| MACCS fingerprints | 0.840 | 0.000 | 0.956 | 0.000 | 0.898 | 0.004 | 0.890 | 0.000 | 0.960 | 0.000 | 0.798 | 0.004 | Download |
| Daylight fingerprints | 0.820 | 0.000 | 0.980 | 0.000 | 0.900 | 0.000 | 0.890 | 0.000 | 0.950 | 0.000 | 0.810 | 0.000 | Download |
| ECFP2 fingerprints | 0.834 | 0.005 | 0.968 | 0.000 | 0.901 | 0.003 | 0.898 | 0.004 | 0.990 | 0.000 | 0.814 | 0.005 | Download |
| ECFP4 fingerprints | 0.830 | 0.000 | 0.990 | 0.000 | 0.910 | 0.000 | 0.901 | 0.003 | 0.990 | 0.000 | 0.831 | 0.003 | Download |
| ECFP6 fingerprints | 0.813 | 0.005 | 0.987 | 0.000 | 0.900 | 0.000 | 0.891 | 0.003 | 0.990 | 0.000 | 0.819 | 0.003 | Download |
| Positive dataset | Negative dataset |
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E-mail: biomed@csu.edu.cn
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