Target name

P31391: Somatostatin receptor type 4


  Protein function

Receptor for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. It is functionally coupled not only to inhibition of adenylate cyclase, but also to activation of both arachidonate release and mitogen-activated protein (MAP) kinase cascade. Mediates antiproliferative action of somatostatin in tumor cells.

  Database links

Uniprot primary ID P31391
PDB ID
DrugBank ID
BioGrid ID 112632
GuidetoPHARMACOLOGY ID 358
PharmGKB ID PA36157
KEGG ID hsa:6754
DIP ID
STRING ID 9606.ENSP00000255008
IntAct ID
DMDM 206729897
BRENDA
Reactome R-HSA-418594 R-HSA-375276
SignaLink
BioCyc
Entrez Gene (Gene ID) 6754
BindingDB

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.830 0.000 0.970 0.000 0.900 0.000 0.890 0.000 0.970 0.000 0.810 0.000 Download
Estate fingerprints 0.860 0.000 0.960 0.000 0.910 0.000 0.908 0.004 0.970 0.000 0.823 0.005 Download
MACCS fingerprints 0.840 0.000 0.956 0.000 0.898 0.004 0.890 0.000 0.960 0.000 0.798 0.004 Download
Daylight fingerprints 0.820 0.000 0.980 0.000 0.900 0.000 0.890 0.000 0.950 0.000 0.810 0.000 Download
ECFP2 fingerprints 0.834 0.005 0.968 0.000 0.901 0.003 0.898 0.004 0.990 0.000 0.814 0.005 Download
ECFP4 fingerprints 0.830 0.000 0.990 0.000 0.910 0.000 0.901 0.003 0.990 0.000 0.831 0.003 Download
ECFP6 fingerprints 0.813 0.005 0.987 0.000 0.900 0.000 0.891 0.003 0.990 0.000 0.819 0.003 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

The recommended browsers: Safari, Firefox, Chrome, IE(Ver.>8).
 E-mail: biomed@csu.edu.cn