Target name

P33533: Delta-type opioid receptor


  Protein function

G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine.

  Database links

Uniprot primary ID P33533
PDB ID
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID 317
PharmGKB ID
KEGG ID rno:24613
DIP ID
STRING ID 10116.ENSRNOP00000014084
IntAct ID
DMDM
BRENDA
Reactome R-RNO-418594 R-RNO-375276
SignaLink
BioCyc
Entrez Gene (Gene ID) 24613
BindingDB P33533

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.883 0.005 0.879 0.000 0.881 0.003 0.881 0.003 0.950 0.000 0.768 0.004 Download
Estate fingerprints 0.904 0.005 0.816 0.004 0.860 0.000 0.869 0.003 0.935 0.005 0.727 0.005 Download
MACCS fingerprints 0.881 0.003 0.817 0.000 0.849 0.003 0.851 0.003 0.940 0.000 0.699 0.003 Download
Daylight fingerprints 0.694 0.005 0.920 0.000 0.807 0.005 0.780 0.000 0.910 0.000 0.628 0.004 Download
ECFP2 fingerprints 0.940 0.000 0.940 0.000 0.940 0.000 0.940 0.000 0.980 0.000 0.880 0.000 Download
ECFP4 fingerprints 0.920 0.000 0.960 0.000 0.940 0.000 0.935 0.005 0.980 0.000 0.871 0.003 Download
ECFP6 fingerprints 0.884 0.005 0.958 0.000 0.921 0.003 0.920 0.000 0.972 0.004 0.850 0.000 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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