Target name

P34969: 5-hydroxytryptamine receptor 7


  Protein function

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.

  Database links

Uniprot primary ID P34969
PDB ID
DrugBank ID DB00751 DB06148 DB01238 DB01049 DB04946 DB00321 DB00934
BioGrid ID 109595
GuidetoPHARMACOLOGY ID 12
PharmGKB ID PA29561
KEGG ID hsa:3363
DIP ID
STRING ID 9606.ENSP00000337949
IntAct ID P34969
DMDM 8488960
BRENDA
Reactome R-HSA-390666 R-HSA-418555
SignaLink
BioCyc
Entrez Gene (Gene ID) 3363
BindingDB P34969

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.809 0.003 0.845 0.005 0.827 0.005 0.821 0.003 0.910 0.000 0.652 0.006 Download
Estate fingerprints 0.835 0.005 0.733 0.005 0.784 0.005 0.795 0.005 0.870 0.000 0.571 0.007 Download
MACCS fingerprints 0.813 0.005 0.743 0.003 0.778 0.004 0.786 0.005 0.870 0.000 0.556 0.005 Download
Daylight fingerprints 0.760 0.000 0.796 0.000 0.778 0.004 0.770 0.000 0.820 0.000 0.551 0.003 Download
ECFP2 fingerprints 0.901 0.003 0.893 0.003 0.897 0.005 0.897 0.005 0.960 0.000 0.789 0.006 Download
ECFP4 fingerprints 0.876 0.005 0.934 0.005 0.905 0.005 0.901 0.003 0.970 0.000 0.812 0.006 Download
ECFP6 fingerprints 0.802 0.004 0.958 0.004 0.880 0.000 0.870 0.000 0.960 0.000 0.769 0.006 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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