Target name

P34972: Cannabinoid receptor 2


  Protein function

Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis.

  Database links

Uniprot primary ID P34972
PDB ID 2KI9
DrugBank ID DB00470 DB00486
BioGrid ID
GuidetoPHARMACOLOGY ID 57
PharmGKB ID PA26682
KEGG ID hsa:1269
DIP ID
STRING ID 9606.ENSP00000363596
IntAct ID P34972
DMDM 461697
BRENDA
Reactome R-HSA-418594 R-HSA-373076
SignaLink
BioCyc
Entrez Gene (Gene ID) 1269
BindingDB P34972

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.792 0.004 0.848 0.000 0.820 0.000 0.820 0.000 0.900 0.000 0.644 0.005 Download
Estate fingerprints 0.758 0.004 0.682 0.003 0.720 0.000 0.730 0.000 0.800 0.000 0.436 0.005 Download
MACCS fingerprints 0.760 0.000 0.718 0.000 0.739 0.003 0.741 0.003 0.820 0.000 0.474 0.005 Download
Daylight fingerprints 0.662 0.004 0.718 0.000 0.690 0.000 0.680 0.000 0.730 0.000 0.380 0.000 Download
ECFP2 fingerprints 0.860 0.000 0.880 0.005 0.870 0.000 0.870 0.000 0.950 0.000 0.748 0.004 Download
ECFP4 fingerprints 0.890 0.000 0.950 0.000 0.920 0.000 0.916 0.005 0.970 0.000 0.836 0.005 Download
ECFP6 fingerprints 0.875 0.005 0.945 0.000 0.910 0.000 0.910 0.000 0.970 0.000 0.829 0.003 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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 E-mail: biomed@csu.edu.cn