Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2. As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH on 'Cys-247' implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM.
| Uniprot primary ID | P35228 |
| PDB ID | 1NSI 3EJ8 4NOS 3E7G 2NSI 3HR4 2LL6 4CX7 |
| DrugBank ID | DB00997 DB01110 DB01234 DB00125 DB00155 DB08814 |
| BioGrid ID | 110906 |
| GuidetoPHARMACOLOGY ID | 1250 |
| PharmGKB ID | PA164724093 |
| KEGG ID | hsa:4843 |
| DIP ID | DIP-59359N |
| STRING ID | 9606.ENSP00000327251 |
| IntAct ID | P35228 |
| DMDM | 1352513 |
| BRENDA | 1.14.13.39 |
| Reactome | R-HSA-1222556 R-HSA-392154 |
| SignaLink | P35228 |
| BioCyc | MetaCyc:HS00205-MONOMER |
| Entrez Gene (Gene ID) | 4843 |
| BindingDB | P35228 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.899 | 0.003 | 0.917 | 0.005 | 0.908 | 0.004 | 0.908 | 0.004 | 0.970 | 0.000 | 0.816 | 0.005 | Download |
| Estate fingerprints | 0.690 | 0.005 | 0.790 | 0.005 | 0.740 | 0.000 | 0.728 | 0.004 | 0.841 | 0.003 | 0.486 | 0.005 | Download |
| MACCS fingerprints | 0.787 | 0.005 | 0.793 | 0.004 | 0.790 | 0.000 | 0.789 | 0.003 | 0.880 | 0.000 | 0.578 | 0.004 | Download |
| Daylight fingerprints | 0.626 | 0.005 | 0.800 | 0.004 | 0.713 | 0.005 | 0.684 | 0.005 | 0.800 | 0.000 | 0.433 | 0.005 | Download |
| ECFP2 fingerprints | 0.945 | 0.005 | 0.935 | 0.000 | 0.940 | 0.000 | 0.940 | 0.000 | 0.990 | 0.000 | 0.882 | 0.006 | Download |
| ECFP4 fingerprints | 0.940 | 0.000 | 0.980 | 0.000 | 0.960 | 0.000 | 0.960 | 0.000 | 0.990 | 0.000 | 0.919 | 0.003 | Download |
| ECFP6 fingerprints | 0.913 | 0.005 | 0.985 | 0.000 | 0.949 | 0.003 | 0.946 | 0.005 | 0.990 | 0.000 | 0.899 | 0.007 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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