Target name

P35228: Nitric oxide synthase, inducible


  Protein function

Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2. As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH on 'Cys-247' implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM.

  Database links

Uniprot primary ID P35228
PDB ID 1NSI 3EJ8 4NOS 3E7G 2NSI 3HR4 2LL6 4CX7
DrugBank ID DB00997 DB01110 DB01234 DB00125 DB00155 DB08814
BioGrid ID 110906
GuidetoPHARMACOLOGY ID 1250
PharmGKB ID PA164724093
KEGG ID hsa:4843
DIP ID DIP-59359N
STRING ID 9606.ENSP00000327251
IntAct ID P35228
DMDM 1352513
BRENDA 1.14.13.39
Reactome R-HSA-1222556 R-HSA-392154
SignaLink P35228
BioCyc MetaCyc:HS00205-MONOMER
Entrez Gene (Gene ID) 4843
BindingDB P35228

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.899 0.003 0.917 0.005 0.908 0.004 0.908 0.004 0.970 0.000 0.816 0.005 Download
Estate fingerprints 0.690 0.005 0.790 0.005 0.740 0.000 0.728 0.004 0.841 0.003 0.486 0.005 Download
MACCS fingerprints 0.787 0.005 0.793 0.004 0.790 0.000 0.789 0.003 0.880 0.000 0.578 0.004 Download
Daylight fingerprints 0.626 0.005 0.800 0.004 0.713 0.005 0.684 0.005 0.800 0.000 0.433 0.005 Download
ECFP2 fingerprints 0.945 0.005 0.935 0.000 0.940 0.000 0.940 0.000 0.990 0.000 0.882 0.006 Download
ECFP4 fingerprints 0.940 0.000 0.980 0.000 0.960 0.000 0.960 0.000 0.990 0.000 0.919 0.003 Download
ECFP6 fingerprints 0.913 0.005 0.985 0.000 0.949 0.003 0.946 0.005 0.990 0.000 0.899 0.007 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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