Target name

P35236: Tyrosine-protein phosphatase non-receptor type 7


  Protein function

Protein phosphatase that acts preferentially on tyrosine-phosphorylated MAPK1. Plays a role in the regulation of T and B-lymphocyte development and signal transduction.

  Database links

Uniprot primary ID P35236
PDB ID 2GPH 2QDP 2HVL 2A3K 3O4T 3O4U 2QDC 3O4S 3D44 2QDM 1ZC0 2GP0 3D42
DrugBank ID
BioGrid ID 111743
GuidetoPHARMACOLOGY ID
PharmGKB ID PA34003
KEGG ID
DIP ID DIP-29118N
STRING ID 9606.ENSP00000309116
IntAct ID P35236
DMDM 20141721
BRENDA 3.1.3.48
Reactome
SignaLink
BioCyc
Entrez Gene (Gene ID) 5778
BindingDB P35236

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.712 0.008 0.916 0.005 0.814 0.005 0.793 0.005 0.889 0.003 0.647 0.009 Download
Estate fingerprints 0.831 0.007 0.803 0.006 0.817 0.005 0.818 0.004 0.883 0.005 0.632 0.010 Download
MACCS fingerprints 0.823 0.008 0.831 0.007 0.827 0.007 0.827 0.007 0.880 0.000 0.652 0.009 Download
Daylight fingerprints 0.731 0.006 0.801 0.011 0.766 0.005 0.757 0.005 0.791 0.003 0.533 0.014 Download
ECFP2 fingerprints 0.894 0.005 0.864 0.007 0.879 0.006 0.883 0.005 0.946 0.005 0.762 0.010 Download
ECFP4 fingerprints 0.844 0.007 0.914 0.006 0.879 0.006 0.876 0.007 0.950 0.000 0.764 0.012 Download
ECFP6 fingerprints 0.790 0.012 0.930 0.003 0.860 0.007 0.850 0.007 0.942 0.004 0.731 0.014 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

The recommended browsers: Safari, Firefox, Chrome, IE(Ver.>8).
 E-mail: biomed@csu.edu.cn