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E-mail: biomed@csu.edu.cn
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G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli.
| Uniprot primary ID | P35353 |
| PDB ID | |
| DrugBank ID | |
| BioGrid ID | 248692 |
| GuidetoPHARMACOLOGY ID | 212 |
| PharmGKB ID | |
| KEGG ID | |
| DIP ID | |
| STRING ID | 10116.ENSRNOP00000006764 |
| IntAct ID | P35353 |
| DMDM | |
| BRENDA | |
| Reactome | R-RNO-373080 R-RNO-418555 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 58959 |
| BindingDB | P35353 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.938 | 0.004 | 0.960 | 0.000 | 0.949 | 0.003 | 0.948 | 0.004 | 0.980 | 0.000 | 0.896 | 0.005 | Download |
| Estate fingerprints | 0.907 | 0.005 | 0.871 | 0.005 | 0.889 | 0.003 | 0.892 | 0.006 | 0.950 | 0.000 | 0.783 | 0.007 | Download |
| MACCS fingerprints | 0.923 | 0.005 | 0.897 | 0.005 | 0.910 | 0.000 | 0.910 | 0.000 | 0.960 | 0.000 | 0.820 | 0.005 | Download |
| Daylight fingerprints | 0.835 | 0.005 | 0.889 | 0.000 | 0.862 | 0.004 | 0.860 | 0.000 | 0.920 | 0.000 | 0.727 | 0.005 | Download |
| ECFP2 fingerprints | 0.980 | 0.000 | 0.980 | 0.000 | 0.980 | 0.000 | 0.980 | 0.000 | 0.990 | 0.000 | 0.970 | 0.000 | Download |
| ECFP4 fingerprints | 0.980 | 0.000 | 1.000 | 0.000 | 0.990 | 0.000 | 0.990 | 0.000 | 0.990 | 0.000 | 0.970 | 0.000 | Download |
| ECFP6 fingerprints | 0.970 | 0.000 | 0.990 | 0.000 | 0.980 | 0.000 | 0.980 | 0.000 | 0.990 | 0.000 | 0.969 | 0.003 | Download |
| Positive dataset | Negative dataset |
The recommended browsers: Safari, Firefox, Chrome, IE(Ver.>8).
E-mail: biomed@csu.edu.cn
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