Target name

P35353: Corticotropin-releasing factor receptor 1


  Protein function

G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli.

  Database links

Uniprot primary ID P35353
PDB ID
DrugBank ID
BioGrid ID 248692
GuidetoPHARMACOLOGY ID 212
PharmGKB ID
KEGG ID
DIP ID
STRING ID 10116.ENSRNOP00000006764
IntAct ID P35353
DMDM
BRENDA
Reactome R-RNO-373080 R-RNO-418555
SignaLink
BioCyc
Entrez Gene (Gene ID) 58959
BindingDB P35353

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.938 0.004 0.960 0.000 0.949 0.003 0.948 0.004 0.980 0.000 0.896 0.005 Download
Estate fingerprints 0.907 0.005 0.871 0.005 0.889 0.003 0.892 0.006 0.950 0.000 0.783 0.007 Download
MACCS fingerprints 0.923 0.005 0.897 0.005 0.910 0.000 0.910 0.000 0.960 0.000 0.820 0.005 Download
Daylight fingerprints 0.835 0.005 0.889 0.000 0.862 0.004 0.860 0.000 0.920 0.000 0.727 0.005 Download
ECFP2 fingerprints 0.980 0.000 0.980 0.000 0.980 0.000 0.980 0.000 0.990 0.000 0.970 0.000 Download
ECFP4 fingerprints 0.980 0.000 1.000 0.000 0.990 0.000 0.990 0.000 0.990 0.000 0.970 0.000 Download
ECFP6 fingerprints 0.970 0.000 0.990 0.000 0.980 0.000 0.980 0.000 0.990 0.000 0.969 0.003 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

The recommended browsers: Safari, Firefox, Chrome, IE(Ver.>8).
 E-mail: biomed@csu.edu.cn