Target name

P35367: Histamine H1 receptor


  Protein function

In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system.

  Database links

Uniprot primary ID P35367
PDB ID 3RZE
DrugBank ID DB00751 DB01146 DB06148 DB00950 DB01142 DB00920 DB00667
BioGrid ID
GuidetoPHARMACOLOGY ID 262
PharmGKB ID PA29456
KEGG ID hsa:3269
DIP ID DIP-41996N
STRING ID 9606.ENSP00000380247
IntAct ID P35367
DMDM 547645
BRENDA
Reactome R-HSA-416476 R-HSA-390650
SignaLink
BioCyc
Entrez Gene (Gene ID) 3269
BindingDB P35367

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.833 0.005 0.847 0.005 0.840 0.000 0.840 0.000 0.910 0.000 0.685 0.007 Download
Estate fingerprints 0.789 0.003 0.751 0.004 0.770 0.000 0.778 0.004 0.840 0.000 0.545 0.007 Download
MACCS fingerprints 0.841 0.003 0.723 0.005 0.782 0.004 0.798 0.004 0.860 0.000 0.571 0.003 Download
Daylight fingerprints 0.826 0.007 0.800 0.004 0.813 0.005 0.815 0.005 0.897 0.005 0.625 0.010 Download
ECFP2 fingerprints 0.901 0.003 0.859 0.004 0.880 0.000 0.881 0.003 0.960 0.000 0.761 0.006 Download
ECFP4 fingerprints 0.873 0.005 0.929 0.005 0.901 0.003 0.900 0.000 0.970 0.000 0.802 0.004 Download
ECFP6 fingerprints 0.831 0.003 0.949 0.004 0.890 0.000 0.881 0.003 0.961 0.003 0.783 0.005 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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