This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes.
| Uniprot primary ID | P35368 |
| PDB ID | |
| DrugBank ID | DB00777 DB06148 DB00598 DB00590 DB01142 DB01049 DB00334 |
| BioGrid ID | 106657 |
| GuidetoPHARMACOLOGY ID | 23 |
| PharmGKB ID | PA33 |
| KEGG ID | hsa:147 |
| DIP ID | DIP-33399N |
| STRING ID | 9606.ENSP00000306662 |
| IntAct ID | P35368 |
| DMDM | 116241241 |
| BRENDA | |
| Reactome | R-HSA-390696 R-HSA-416476 R-HSA-416482 |
| SignaLink | P35368 |
| BioCyc | |
| Entrez Gene (Gene ID) | 147 |
| BindingDB | P35368 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.767 | 0.007 | 0.905 | 0.003 | 0.836 | 0.005 | 0.825 | 0.005 | 0.920 | 0.000 | 0.678 | 0.006 | Download |
| Estate fingerprints | 0.815 | 0.005 | 0.723 | 0.003 | 0.769 | 0.003 | 0.779 | 0.003 | 0.840 | 0.000 | 0.538 | 0.004 | Download |
| MACCS fingerprints | 0.866 | 0.005 | 0.778 | 0.005 | 0.822 | 0.004 | 0.830 | 0.000 | 0.890 | 0.000 | 0.645 | 0.005 | Download |
| Daylight fingerprints | 0.701 | 0.003 | 0.919 | 0.005 | 0.810 | 0.000 | 0.788 | 0.004 | 0.850 | 0.000 | 0.634 | 0.005 | Download |
| ECFP2 fingerprints | 0.870 | 0.000 | 0.930 | 0.005 | 0.900 | 0.000 | 0.894 | 0.005 | 0.970 | 0.000 | 0.798 | 0.004 | Download |
| ECFP4 fingerprints | 0.861 | 0.003 | 0.977 | 0.000 | 0.919 | 0.003 | 0.910 | 0.000 | 0.980 | 0.000 | 0.839 | 0.003 | Download |
| ECFP6 fingerprints | 0.820 | 0.000 | 0.980 | 0.003 | 0.900 | 0.000 | 0.892 | 0.004 | 0.979 | 0.003 | 0.817 | 0.005 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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