Target name

P35368: Alpha-1B adrenergic receptor


  Protein function

This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes.

  Database links

Uniprot primary ID P35368
PDB ID
DrugBank ID DB00777 DB06148 DB00598 DB00590 DB01142 DB01049 DB00334
BioGrid ID 106657
GuidetoPHARMACOLOGY ID 23
PharmGKB ID PA33
KEGG ID hsa:147
DIP ID DIP-33399N
STRING ID 9606.ENSP00000306662
IntAct ID P35368
DMDM 116241241
BRENDA
Reactome R-HSA-390696 R-HSA-416476 R-HSA-416482
SignaLink P35368
BioCyc
Entrez Gene (Gene ID) 147
BindingDB P35368

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.767 0.007 0.905 0.003 0.836 0.005 0.825 0.005 0.920 0.000 0.678 0.006 Download
Estate fingerprints 0.815 0.005 0.723 0.003 0.769 0.003 0.779 0.003 0.840 0.000 0.538 0.004 Download
MACCS fingerprints 0.866 0.005 0.778 0.005 0.822 0.004 0.830 0.000 0.890 0.000 0.645 0.005 Download
Daylight fingerprints 0.701 0.003 0.919 0.005 0.810 0.000 0.788 0.004 0.850 0.000 0.634 0.005 Download
ECFP2 fingerprints 0.870 0.000 0.930 0.005 0.900 0.000 0.894 0.005 0.970 0.000 0.798 0.004 Download
ECFP4 fingerprints 0.861 0.003 0.977 0.000 0.919 0.003 0.910 0.000 0.980 0.000 0.839 0.003 Download
ECFP6 fingerprints 0.820 0.000 0.980 0.003 0.900 0.000 0.892 0.004 0.979 0.003 0.817 0.005 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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