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E-mail: biomed@csu.edu.cn
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Catalyzes the initial step in utilization of glucose by the beta-cell and liver at physiological glucose concentration. Glucokinase has a high Km for glucose, and so it is effective only when glucose is abundant. The role of GCK is to provide G6P for the synthesis of glycogen. Pancreatic glucokinase plays an important role in modulating insulin secretion. Hepatic glucokinase helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage.
| Uniprot primary ID | P35557 |
| PDB ID | 4ISE 4ISF 4ISG 3IDH 3H1V 3FR0 4DHY 1GLK 3A0I 3VEV 3GOI 4IXC 3VEY 3FGU 3S41 4NO7 4L3Q 3F9M 3ID8 1V4T 4LC9 1V4S 4IWV 3IMX 4DCH 4MLH 3VF6 3QIC 4RCH 4MLE |
| DrugBank ID | |
| BioGrid ID | 108915 |
| GuidetoPHARMACOLOGY ID | 2798 |
| PharmGKB ID | PA28610 |
| KEGG ID | hsa:2645 |
| DIP ID | |
| STRING ID | 9606.ENSP00000223366 |
| IntAct ID | P35557 |
| DMDM | 547696 |
| BRENDA | 2.7.1.1 2.7.1.2 |
| Reactome | R-HSA-210745 R-HSA-70171 R-HSA-70153 R-HSA-170822 |
| SignaLink | |
| BioCyc | MetaCyc:HS02935-MONOMER |
| Entrez Gene (Gene ID) | 2645 |
| BindingDB | P35557 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.953 | 0.007 | 0.985 | 0.000 | 0.969 | 0.003 | 0.969 | 0.003 | 0.990 | 0.000 | 0.941 | 0.006 | Download |
| Estate fingerprints | 0.868 | 0.008 | 0.828 | 0.003 | 0.848 | 0.006 | 0.854 | 0.005 | 0.940 | 0.000 | 0.700 | 0.008 | Download |
| MACCS fingerprints | 0.909 | 0.003 | 0.911 | 0.003 | 0.910 | 0.000 | 0.910 | 0.000 | 0.960 | 0.000 | 0.821 | 0.003 | Download |
| Daylight fingerprints | 0.925 | 0.005 | 0.995 | 0.000 | 0.960 | 0.000 | 0.959 | 0.003 | 0.988 | 0.004 | 0.919 | 0.003 | Download |
| ECFP2 fingerprints | 0.980 | 0.000 | 0.980 | 0.005 | 0.980 | 0.000 | 0.980 | 0.000 | 0.990 | 0.000 | 0.961 | 0.003 | Download |
| ECFP4 fingerprints | 0.980 | 0.000 | 1.000 | 0.000 | 0.990 | 0.000 | 0.990 | 0.000 | 0.990 | 0.000 | 0.972 | 0.004 | Download |
| ECFP6 fingerprints | 0.970 | 0.000 | 0.998 | 0.000 | 0.984 | 0.005 | 0.984 | 0.005 | 0.990 | 0.000 | 0.967 | 0.005 | Download |
| Positive dataset | Negative dataset |
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E-mail: biomed@csu.edu.cn
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