Target name

P35557: Glucokinase


  Protein function

Catalyzes the initial step in utilization of glucose by the beta-cell and liver at physiological glucose concentration. Glucokinase has a high Km for glucose, and so it is effective only when glucose is abundant. The role of GCK is to provide G6P for the synthesis of glycogen. Pancreatic glucokinase plays an important role in modulating insulin secretion. Hepatic glucokinase helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage.

  Database links

Uniprot primary ID P35557
PDB ID 4ISE 4ISF 4ISG 3IDH 3H1V 3FR0 4DHY 1GLK 3A0I 3VEV 3GOI 4IXC 3VEY 3FGU 3S41 4NO7 4L3Q 3F9M 3ID8 1V4T 4LC9 1V4S 4IWV 3IMX 4DCH 4MLH 3VF6 3QIC 4RCH 4MLE
DrugBank ID
BioGrid ID 108915
GuidetoPHARMACOLOGY ID 2798
PharmGKB ID PA28610
KEGG ID hsa:2645
DIP ID
STRING ID 9606.ENSP00000223366
IntAct ID P35557
DMDM 547696
BRENDA 2.7.1.1 2.7.1.2
Reactome R-HSA-210745 R-HSA-70171 R-HSA-70153 R-HSA-170822
SignaLink
BioCyc MetaCyc:HS02935-MONOMER
Entrez Gene (Gene ID) 2645
BindingDB P35557

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.953 0.007 0.985 0.000 0.969 0.003 0.969 0.003 0.990 0.000 0.941 0.006 Download
Estate fingerprints 0.868 0.008 0.828 0.003 0.848 0.006 0.854 0.005 0.940 0.000 0.700 0.008 Download
MACCS fingerprints 0.909 0.003 0.911 0.003 0.910 0.000 0.910 0.000 0.960 0.000 0.821 0.003 Download
Daylight fingerprints 0.925 0.005 0.995 0.000 0.960 0.000 0.959 0.003 0.988 0.004 0.919 0.003 Download
ECFP2 fingerprints 0.980 0.000 0.980 0.005 0.980 0.000 0.980 0.000 0.990 0.000 0.961 0.003 Download
ECFP4 fingerprints 0.980 0.000 1.000 0.000 0.990 0.000 0.990 0.000 0.990 0.000 0.972 0.004 Download
ECFP6 fingerprints 0.970 0.000 0.998 0.000 0.984 0.005 0.984 0.005 0.990 0.000 0.967 0.005 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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